Chemistry:Eltoprazine

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Short description: Chemical compound
Eltoprazine
Eltoprazine.png
Clinical data
Other namesDU-28,853; DU-28853
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC12H16N2O2
Molar mass220.272 g·mol−1
3D model (JSmol)

Eltoprazine (developmental code name DU-28,853) is a serotonergic drug of the phenylpiperazine class which is described as a serenic or antiaggressive agent.[1][2][3] It acts as an agonist of the serotonin 5-HT1A and 5-HT1B receptors and as an antagonist of the serotonin 5-HT2C receptor.[3][4] The drug is closely related to fluprazine and batoprazine, which are similarly acting agents, and is also a known chemical precursor to S-15535 and lecozotan. Eltoprazine is or was under development for the treatment of aggression, attention deficit hyperactivity disorder (ADHD), cognition disorders, and drug-induced dyskinesia, but no recent development has been reported for these indications as of February 2022.[1] It was also under development for the treatment of psychotic disorders, but development for this indication was discontinued.[1] Eltoprazine was originated by Solvay and was developed by Elto Pharma, PsychoGenics, and Solvay.[1]

References

  1. ↑ 1.0 1.1 1.2 1.3 "Eltoprazine - Elto Pharma - AdisInsight". https://adisinsight.springer.com/drugs/800000719. 
  2. ↑ "Behavioural pharmacology of the serenic, eltoprazine". Drug Metabol Drug Interact. 8 (1–2): 31–83. 1990. doi:10.1515/DMDI.1990.8.1-2.31. PMID 2091890. 
  3. ↑ 3.0 3.1 "5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis". Eur J Pharmacol 526 (1–3): 125–39. December 2005. doi:10.1016/j.ejphar.2005.09.065. PMID 16310183. 
  4. ↑ "Neurochemical profile of eltoprazine.". Drug Metabol Drug Interact. 8 (1–2): 85–114. 1990. doi:10.1515/dmdi.1990.8.1-2.85. PMID 1982626. 

External links



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