Chemistry:DHA-clozapine

Short description: Chemical compound

DHA-clozapine

Clinical data
Trade names	Clozaprexin
Other names	Docosahexaenoyl clozapine
ATC code	none
Legal status
Legal status	US: Investigational New Drug
Identifiers
IUPAC name (4Z,7Z,10Z,13Z,16Z,19Z)-1-[3-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzodiazepin-11-yl]docosa-4,7,10,13,16,19-hexaen-1-one
CAS Number	225916-82-5 Y
PubChem CID	9852332
ChemSpider	8028044 N
UNII	Q5Q5VSN8DL
Chemical and physical data
Formula	C40H49ClN4O
Molar mass	637.31 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc1ccc2N(C(=O)CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CC)c4ccccc4C(=N/c2c1)\N3CCN(C)CC3
InChI InChI=1S/C40H49ClN4O/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-26-39(46)45-37-25-23-22-24-35(37)40(44-31-29-43(2)30-32-44)42-36-33-34(41)27-28-38(36)45/h4-5,7-8,10-11,13-14,16-17,19-20,22-25,27-28,33H,3,6,9,12,15,18,21,26,29-32H2,1-2H3/b5-4-,8-7-,11-10-,14-13-,17-16-,20-19- N Key:RPSJOJIGGSRDMO-JDPCYWKWSA-N N
NY (what is this?)  (verify)

DHA-clozapine (tentative trade name Clozaprexin) is an atypical antipsychotic drug candidate that was created and originally tested by chemists at Protarga, a small pharmaceutical in Pennsylvania, and scientists at Harvard University.

It is a prodrug of clozapine; the fatty acid docosahexaenoic acid (DHA) was added to clozapine in order to increase penetration of the blood–brain barrier.

Protarga was purchased by Luitpold Pharmaceuticals in 2003 and development was discontinued in 2007.