Chemistry:Quilostigmine
From HandWiki
Quilostigmine, also known as NXX-066, is an acetylcholinesterase inhibitor. Its structure is related to that of physostigmine,[1] another acetylcholinesterase (AChE) inhibitor.
Biological activity
Quilostigmine displays inhibition of the AChE enzyme with an Template:IC50 value of 0.148 µM.[2]
History
Quilostigmine was initially studied by AstraZeneca for the treatment of Alzheimer's disease;[3][4] however, the drug appears to have been discontinued,[5] reaching a maximum trial phase of two.[6]
References
- ↑ PubChem. "Quilostigmine" (in en). https://pubchem.ncbi.nlm.nih.gov/compound/132228.
- ↑ "AID 511766 - Inhibition of human AChE by Ellmans test - PubChem". https://pubchem.ncbi.nlm.nih.gov/bioassay/511766.
- ↑ Sramek, J. J.; Hourani, J.; Jhee, S. S.; Cutler, N. R. (1999). "NXX-066 in patients with Alzheimer's disease: a bridging study". Life Sciences 64 (14): 1215–1221. doi:10.1016/s0024-3205(99)00053-3. ISSN 0024-3205. PMID 10210264.
- ↑ "Case No COMP/M.1878 - PFIZER / WARNER- LAMBERT". https://ec.europa.eu/competition/mergers/cases/decisions/m1878_en.pdf.
- ↑ "Quilostigmine - AdisInsight". https://adisinsight.springer.com/drugs/800006532.
- ↑ "Delving into the Latest Updates on Quilostigmine with Synapse" (in en). https://synapse.patsnap.com/drug/fbb0ed5c12434104981d1586c35af06c.
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