Biology:Excitatory amino-acid transporter 4
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Excitatory amino-acid transporter 4 (EAAT4) is a protein that in humans is encoded by the SLC1A6 gene.[1][2]
EAAT4 is expressed predominantly in the cerebellum, has high affinity for the excitatory amino acids L-aspartate and L-glutamate. When stimulated by these amino acids, EAAT4 conducts chloride ions.[2]
References
- ↑ "Entrez Gene: solute carrier family 1 (high affinity aspartate/glutamate transporter)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6511.
- ↑ 2.0 2.1 "An excitatory amino-acid transporter with properties of a ligand-gated chloride channel". Nature 375 (6532): 599–603. June 1995. doi:10.1038/375599a0. PMID 7791878.
Further reading
- "Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (3): 271–8. 2007. doi:10.1002/ajmg.b.30351. PMID 17221839.
- "Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.". Eur. J. Hum. Genet. 17 (7): 946–57. 2009. doi:10.1038/ejhg.2008.264. PMID 19156168.
- "Niflumic acid modulates uncoupled substrate-gated conductances in the human glutamate transporter EAAT4.". J. Physiol. 534 (Pt 1): 159–67. 2001. doi:10.1111/j.1469-7793.2001.00159.x. PMID 11432999.
- "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- "The glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunits.". J. Neurosci. 27 (11): 2943–7. 2007. doi:10.1523/JNEUROSCI.0118-07.2007. PMID 17360917.
- "Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins.". Nature 410 (6824): 89–93. 2001. doi:10.1038/35065091. PMID 11242047.
- "EAAT4 phosphorylation at the SGK1 consensus site is required for transport modulation by the kinase.". J. Neurochem. 102 (3): 858–66. 2007. doi:10.1111/j.1471-4159.2007.04585.x. PMID 17442044.
- "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. 2009. doi:10.1002/ajmg.b.30902. PMID 19086053.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932.
- "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. 2004. doi:10.1038/nature02399. PMID 15057824.
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