Biology:Excitatory amino-acid transporter 5
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 Generic protein structure example |
Excitatory amino-acid transporter 5 (EAAT5) is a protein that in humans is encoded by the SLC1A7 gene.[1][2]
EAAT5 is expressed predominantly in the retina, has high affinity for the excitatory amino acid L-glutamate. When stimulated by this amino acid, EAAT5 conducts chloride ions.[2]
References
- ↑ "Entrez Gene: solute carrier family 1 (glutamate transporter)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6512.
- ↑ 2.0 2.1 "Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance". Proc. Natl. Acad. Sci. U.S.A. 94 (8): 4155–60. April 1997. doi:10.1073/pnas.94.8.4155. PMID 9108121.
Further reading
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932.
- "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium.". Mol. Vis. 8: 185–95. 2002. PMID 12107412.
- "Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3.". Biochem. Biophys. Res. Commun. 329 (2): 738–42. 2005. doi:10.1016/j.bbrc.2005.02.035. PMID 15737648.
- "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. 2009. doi:10.1002/ajmg.b.30902. PMID 19086053.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
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