Chemistry:5,7-Dihydroxytryptamine
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| Preferred IUPAC name
3-(2-Aminoethyl)-1H-indole-5,7-diol | |
| Other names
5,7-Dihydroxytryptamine
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| Properties | |
| C10H12N2O2 | |
| Molar mass | 192.214 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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5,7-Dihydroxytryptamine (5,7-DHT) is a purported neurotoxin[1][2] used in scientific research to decrease concentrations of serotonin in the brain. The mechanism behind this effect is not well understood, but it is speculated to selectively destroy serotonergic neurons, in a manner similar to the dopaminergic neurotoxicity of 6-hydroxydopamine (6-OHDA). What is known is that this compound is in fact not selective in depleting serotonin content, but also depletes norepinephrine. To selectively deplete serotonin stores, it is commonly administered in conjunction with desmethylimipramine (desipramine),[3] which inhibits the norepinephrine transporter.
See also
- DSP-4
- 6-Hydroxydopamine (6-OHDA)
- para-Chlorophenylalanine (PCPA)
References
- ↑ Cairncross, KD; Cox, B; Forster, C; Wren, A (1977). "The ability of local injection of 6-OHDA, 5,6-DHT and 5,7-DHT into the olfactory bulbs to mimic the effects of bilateral bulbectomy in the rat proceedings". British Journal of Pharmacology 61 (1): 145P–146P. doi:10.1111/j.1476-5381.1977.tb09748.x. PMID 912193.
- ↑ Liu, J; Chu, YX; Zhang, QJ; Wang, S; Feng, J; Li, Q (2007). "5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters neuronal activity of the subthalamic nucleus in normal and 6-hydroxydopamine-lesioned rats". Brain Research 1149: 216–22. doi:10.1016/j.brainres.2007.02.052. PMID 17376410.
- ↑ Martin-Iverson, M.T., Leclere, J.F. and Fibiger, H.C., Cholinergic-dopaminergic interactions and the mechanisms of action of antidepressants, European Journal of Pharmacology, 94 (1983) 193–201.
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