Biology:Sodium- and chloride-dependent betaine transporter

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example


Sodium- and chloride-dependent betaine transporter, also known as Na(+)/Cl(-) betaine/GABA transporter (BGT-1), is a protein that in humans is encoded by the SLC6A12 gene. BGT-1 is predominantly expressed in the liver (hepatocytes).[1] It is also expressed in the kidney[1] where it is regulated by NFAT5 during a response to osmotic stress.[2] Further, BGT1 is also present in the leptomeninges surrounding the brain.[1] Deletion of the BGT1 gene in mice did not appear to have any impact on the tendency to develop epilepsy.[3] This is to be expected considering that BGT1 is expressed at far lower levels than GAT1 and also has lower affinity for GABA. This implies that it is not likely to contribute significantly to the inactivation of the inhibitory neurotransmitter GABA.[3]

See also

References

  1. ↑ 1.0 1.1 1.2 "The betaine-GABA transporter (BGT1, slc6a12) is predominantly expressed in the liver and at lower levels in the kidneys and at the brain surface". Am J Physiol Renal Physiol 302 (3): F316-28. 2012. doi:10.1152/ajprenal.00464.2011. PMID 22071246. 
  2. ↑ "TonEBP stimulates multiple cellular pathways for adaptation to hypertonic stress: Organic osmolyte-dependent and -independent pathways". AJP: Renal Physiology 300 (3): F707–F715. 2011. doi:10.1152/ajprenal.00227.2010. PMID 21209002. 
  3. ↑ 3.0 3.1 "Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice". Epilepsy Res 95 (1–2): 70–81. 2011. doi:10.1016/j.eplepsyres.2011.02.014. PMID 21459558. 




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