Chemistry:Mirodenafil
From HandWiki
Mirodenafil belongs to the drug class PDE5 inhibitors, which includes avanafil, sildenafil, tadalafil, udenafil, and vardenafil, and is the first-line treatment for erectile dysfunction. Developed by SK Chemicals Life Science, mirodenafil is marketed in Korea under the trade name Mvix, offered both as tablets (50 mg and 100 mg) and as orally dissolving films (50 mg).
Despite several clinical trials having been conducted,[1][2][3] mirodenafil has not been approved for use in the United States by the U.S. Food and Drug Administration.
References
- ↑ "Efficacy and safety of mirodenafil, a new oral phosphodiesterase type 5 inhibitor, for treatment of erectile dysfunction". The Journal of Sexual Medicine 5 (11): 2672–80. November 2008. doi:10.1111/j.1743-6109.2008.00945.x. PMID 18638004.
- ↑ "Influence of alcohol on the hemodynamic effects and pharmacokinetic properties of mirodenafil: a single-dose, randomized-sequence, open-label, crossover study in healthy male volunteers in Korea". Clinical Therapeutics 31 (6): 1234–43. June 2009. doi:10.1016/j.clinthera.2009.06.008. PMID 19695390.
- ↑ "The effects of ketoconazole and rifampicin on the pharmacokinetics of mirodenafil in healthy Korean male volunteers: an open-label, one-sequence, three-period, three-treatment crossover study". Clinical Therapeutics 31 (12): 3009–20. December 2009. doi:10.1016/j.clinthera.2009.12.012. PMID 20110038.
{{Navbox
| name = Sexual dysfunction pharmacotherapies | title = Sexual dysfunction pharmacotherapies | state = autocollapse | bodyclass = hlist | listclass = hlist
| group1 = Dopamine agonists | list1 =
- Apomorphine
- Cabergoline
- Lisuride
- Pergolide
- Piribedil
- Pramipexole
- Quinagolide
- Ropinirole
- Rotigotine
- Terguride
| group2 = Melanocortin agonists | list2 =
| group3 = PDE5 inhibitors | list3 =
- Acetildenafil
- Aildenafil
- Avanafil
- Icariin
- Lodenafil
- Mirodenafil
- Nitrosoprodenafil
- Sildenafil
- Sulfoaildenafil
- Tadalafil
- Udenafil
- Vardenafil
| group4 = Sex steroids | list4 =
- Androgens (e.g., [[testosterone, methyltestosterone, other anabolic steroids)
- Estrogens (e.g., [[estradiol, ethinylestradiol, conjugated equine estrogens (Premarin))
- Progestogens (e.g., [[progesterone, progestins)
- Mixed (e.g., tibolone)
| group5 = Others | list5 =
- Afrodor (acecarbromal, quebracho, vitamin E)
- Alkyl nitrites
- Alprostadil
- Amantadine
- Bupropion
- Buspirone
- Cyproheptadine
- Dapoxetine
- Flibanserin
- Mirtazapine
- Moxisylyte
- Oxytocin
- Papaverine
- Phentolamine
- Psychostimulants (e.g., amphetamines, cocaine, methylphenidate)
- Rauwolscine (Rauvolfia)
- Trazodone
- Yohimbine (Yohimbe)
| below =
}}
 |  |
