Biology:TGF beta receptor
transforming growth factor beta, receptor type I (activin A receptor type II-like kinase, 53kDa) | |
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Identifiers | |
Symbol | TGFBR1 |
Alt. symbols | ALK5 |
NCBI gene | 7046 |
HGNC | 11772 |
OMIM | 190181 |
RefSeq | NM_004612 |
UniProt | P36897 |
Other data | |
Locus | Chr. 9 q22 |
transforming growth factor beta, receptor type II (70/80kDa) | |
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Identifiers | |
Symbol | TGFBR2 |
Alt. symbols | MFS2 |
NCBI gene | 7048 |
HGNC | 11773 |
OMIM | 190182 |
RefSeq | NM_001024847 |
UniProt | P37173 |
Other data | |
Locus | Chr. 3 p24.1 |
transforming growth factor beta, receptor type III | |
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Identifiers | |
Symbol | TGFBR3 |
Alt. symbols | β-Glycan |
NCBI gene | 7049 |
HGNC | 11774 |
OMIM | 600742 |
RefSeq | NM_003243 |
UniProt | Q03167 |
Other data | |
Locus | Chr. 1 p33-p32 |
Transforming growth factor beta (TGFβ) receptors are single pass serine/threonine kinase receptors that belong to TGFβ receptor family. They exist in several different isoforms that can be homo- or heterodimeric.[1] The number of characterized ligands in the TGFβ superfamily far exceeds the number of known receptors, suggesting the promiscuity that exists between the ligand and receptor interactions.
TGFβ is a growth factor and cytokine involved in paracrine signalling and can be found in many different tissue types, including brain, heart, kidney, liver, bone, and testes. Over-expression of TGFβ can induce renal fibrosis, causing kidney disease, as well as diabetes, and ultimately end-stage renal disease. Recent developments have found that, using certain types of protein antagonists against TGFβ receptors, can halt and in some cases reverse the effects of renal fibrosis.[citation needed]
Three TGFβ superfamily receptors specific for TGFβ, the TGFβ receptors, can be distinguished by their structural and functional properties. TGFβR1 (ALK5) and TGFβR2 have similar ligand-binding affinities and can be distinguished from each other only by peptide mapping. Both TGFβR1 and TGFβR2 have a high affinity for TGFβ1 and low affinity for TGFβ2. TGFβR3 (β-glycan) has a high affinity for both homodimeric TGFβ1 and TGFβ2 and in addition the heterodimer TGF-β1.2.[2] The TGFβ receptors also bind TGFβ3.
See also
- TGFβ superfamily receptor
- TGFβ signaling pathway
- TGFβ superfamily
References
- ↑ "Heteromeric and homomeric transforming growth factor-beta receptors show distinct signaling and endocytic responses in epithelial cells". The Journal of Biological Chemistry 273 (48): 31770–7. November 1998. doi:10.1074/jbc.273.48.31770. PMID 9822641. (free full text)
- ↑ "The transforming growth factor-beta receptor type III is a membrane proteoglycan. Domain structure of the receptor". The Journal of Biological Chemistry 263 (32): 16984–91. November 1988. doi:10.1016/S0021-9258(18)37487-8. PMID 2903157.
External links
- TGF-beta+Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
![]() | Original source: https://en.wikipedia.org/wiki/TGF beta receptor.
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