Biology:Zinc transporter SLC39A7
 Generic protein structure example |
Zinc transporter SLC39A7 (ZIP7), also known as solute carrier family 39 member 7, is a protein that in humans is encoded by the SLC39A7 gene.[1][2][3] Its fruit fly orthologue is Catsup.
Function
Zinc is an essential cofactor for more than 50 classes of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. Zinc cannot passively diffuse across cell membranes and requires specific transporters, such as SLC39A7, to enter the cytosol from both the extracellular environment and from intracellular storage compartments.[3]
ZIP7 is a membrane transport protein of the endoplasmic reticulum.[4] Phosphorylation of ZIP7 by casein kinase 2 stimulates the release of zinc ions from the endoplasmic reticulum[5] This provides a signal transduction pathway by which activation of cell surface receptors such as the epidermal growth factor receptor can regulate the activity of downstream phosphatases and kinases.
See also
References
- ↑ "cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region". Genomics 35 (3): 600–2. Dec 1996. doi:10.1006/geno.1996.0405. PMID 8812499.
- ↑ "Colinearity of novel genes in the class II regions of the MHC in mouse and human". Immunogenetics 34 (1): 5–11. Aug 1991. doi:10.1007/BF00212306. PMID 1855816.
- ↑ 3.0 3.1 "Entrez Gene: SLC39A7 solute carrier family 39 (zinc transporter), member 7". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7922.
- ↑ "Structure‒function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters". Biochemical Journal 377 (Pt 1): 131–139. 2004. doi:10.1042/BJ20031183. PMID 14525538.
- ↑ "Protein kinase CK2 opens the gate for zinc signaling". Cell Cycle 11 (10): 1863–1864. 2012. doi:10.4161/cc.20414. PMID 22580452.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters". Biochem. J. 375 (Pt 1): 51–9. 2003. doi:10.1042/BJ20030478. PMID 12839489.
- "Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters". Biochem. J. 377 (Pt 1): 131–9. 2004. doi:10.1042/BJ20031183. PMID 14525538.
- "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. 2003. doi:10.1038/nature02055. PMID 14574404. Bibcode: 2003Natur.425..805M.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus". J. Biol. Chem. 280 (15): 15456–63. 2005. doi:10.1074/jbc.M412188200. PMID 15705588.
- "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. 2005. doi:10.1021/pr050048h. PMID 16083285.
- "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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