Chemistry:Pyrrolobenzodiazepine
From HandWiki
Pyrrolobenzodiazepines, (PBD) are a class of compound that may have antibiotic or anti-tumor properties.[1]
Some dimeric pyrrolobenzodiazepines are used as the cytotoxic drug payloads in antibody-drug conjugates, for example in loncastuximab tesirine.
History
Anthramycin, the first PBD monomer, was first synthesized in the 1960s.[2]
References
- ↑ "The development of pyrrolobenzodiazepines as antitumour agents". Expert Opinion on Investigational Drugs 20 (6): 733–44. June 2011. doi:10.1517/13543784.2011.573477. PMID 21457108.
- ↑ From Anthramycin to Pyrrolobenzodiazepine (PBD)‐Containing Antibody–Drug Conjugates (ADCs) Angew Chem Int Ed Engl. 2017 Jan 9; 56(2): 462–488. Published online 2016 Nov 15. doi: 10.1002/anie.201510610
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