Chemistry:Lofendazam
From HandWiki
Short description: Chemical compound
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| Formula | C15H13ClN2O |
| Molar mass | 272.73 g·mol−1 |
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Lofendazam[1] is an organic molecule which is a benzodiazepine derivative. Lofendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring; therefore, lofendazam is most closely related to other 1,5-benzodiazepines such as clobazam.[2][3]
Lofendazam as a human pharmaceutical has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives. It is an active metabolite of another benzodiazepine, arfendazam.[4]
See also
References
- ↑ DE patent 1929656
- ↑ "Syntheses and CD studies of optically active substituted 1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-ones.". Liebigs Annalen der Chemie 1995 (10): 1861–1869. 1995. doi:10.1002/jlac.1995199510261.
- ↑ "Nuclear magnetic resonance spectra of psychotherapeutic agents. V* - conformational analysis of 1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-ones.". Organic Magnetic Resonance 15 (4): 394–398. 1981. doi:10.1002/mrc.1270150414.
- ↑ The Pharmacology of Sleep. Springer. 11 December 1995. ISBN 978-3-540-58961-7.
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