Chemistry:Avizafone
From HandWiki
Avizafone[1] (Pro-Diazepam) is a water-soluble prodrug of the benzodiazepine derivative diazepam. It can be administered intramuscularly.
Avizafone is metabolised by enzymes in the blood to form the active drug diazepam. It has been researched as an alternative to diazepam as an antidote to poisoning with organophosphate nerve agents.[2][3][4]
See also
- Alprazolam triazolobenzophenone
- Clonazafone desglycyl[5]
- Diclazafone desglycyl
- Noravizafone desglycyl
- Rilmazafone
References
- ↑ GB patent 1517164
- ↑ "On the use of diazepam and pro-diazepam (2-benzoyl-4-chloro-N-methyl-N-lysylglycin anilide), as adjunct antidotes in the treatment of organophosphorus intoxication in the guinea-pig". The Journal of Pharmacy and Pharmacology 42 (4): 247–51. April 1990. doi:10.1111/j.2042-7158.1990.tb05401.x. PMID 1974291.
- ↑ "Compared efficacy of diazepam or avizafone to prevent soman-induced electroencephalographic disturbances and neuropathology in primates: relationship to plasmatic benzodiazepine pharmacokinetics". Archives of Toxicology 74 (8): 480–6. October 2000. doi:10.1007/s002040000146. PMID 11097386.
- ↑ "Comparative efficacy of diazepam and avizafone against sarin-induced neuropathology and respiratory failure in guinea pigs: influence of atropine dose". Toxicology 188 (2–3): 197–209. June 2003. doi:10.1016/s0300-483x(03)00086-6. PMID 12767691.
- ↑ "European Drug Report 2025 – Full Book". European Union Drugs Agency (euda.europa.eu). 6 June 2025. https://www.euda.europa.eu/system/files/documents/2025-06/edr-2025-full-book-6.06.2025-en.pdf.
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