Chemistry:Irazepine
From HandWiki
Short description: Chemical compound
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| Formula | C18H13ClFN3OS |
| Molar mass | 373.83 g·mol−1 |
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Irazepine (Ro 7-1986/1) is a benzodiazepine derivative containing isothiocyanate functional group.[1] It is a non-competitive benzodiazepine binding site antagonist.[2] Irazepine and other alkylating benzodiazepines, such as kenazepine, bind to brain benzodiazepine receptors in a non-competitive (covalent) fashion in vitro, and may exert a long-lasting anticonvulsant effect.[3]
References
- ↑ Dictionary of Pharmacological Agents. (1st ed.). London: Chapman & Hall. 1999. ISBN 9780412466304.
- ↑ Concise Dictionary of Pharmacological Agents Properties and Synonyms. Dordrecht: Springer Netherlands. 1999. p. 156. ISBN 978-94-011-4439-1.
- ↑ "In vivo effects of two novel alkylating benzodiazepines, irazepine and kenazepine". Pharmacology, Biochemistry, and Behavior 14 (4): 487–91. April 1981. doi:10.1016/0091-3057(81)90307-5. PMID 7232472.
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