Chemistry:GL-II-73
From HandWiki
Short description: Chemical compound
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| Formula | C23H19FN4O |
| Molar mass | 386.430 g·mol−1 |
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GL-II-73 (GL-ii-073) is a benzodiazepine derivative related in chemical structure to compounds such as midazolam and adinazolam. It is described as an α5 preferring positive allosteric modulator of the benzodiazepine site of GABAA receptors, with weaker activity at α2 and α3 and no significant affinity for the α1 subtype. In animal tests it was found to produce effects consistent with antidepressant, anxiolytic and nootropic actions.[1][2][3][4][5][6][7]
See also
- Imidazenil
- Pyeazolam
- QH-II-66
- SH-I-048A
- SH-053-R-CH3-2'F
- Ro4938581
References
- ↑ Cook JM, Li G, Poe M, Savic M, Sibille E, "Treatment of cognitive and mood symptoms in neurodegenerative and neuropsychiatric disorders with alpha5-containing gabaa receptor agonists.", CA patent 3016491, published 21 September 2017, assigned to Centre for Addiction and Mental Health, Faculty Of Pharmacy, University of Belgradeand UWM Res Foundation Inc
- ↑ "Potential combined pro-cognitive, anxiolytic and antidepressant properties of novel GABAA receptor positive modulators with preferential efficacy at the α5-subunit.". bioRxiv: 332908. January 2018. doi:10.1101/332908. https://www.biorxiv.org/content/biorxiv/early/2018/05/29/332908.full.pdf.
- ↑ "Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive Profiles". Molecular Neuropsychiatry 5 (2): 84–97. April 2019. doi:10.1159/000496086. PMID 31192221.
- ↑ Sibille, Etienne (February 2019). "Brain Inhibitory GABAergic Function and Cognitive Deficits: Mechanisms and Therapeutic Targeting.". Presentation for AAAS. https://www.sibillelab.com/wp-content/uploads/2019/02/AAAS-Sibille.pdf.
- ↑ "Subtype Selective γ-Aminobutyric Acid Type A Receptor (GABAAR) Modulators Acting at the Benzodiazepine Binding Site: An Update". Journal of Medicinal Chemistry 63 (7): 3425–3446. April 2020. doi:10.1021/acs.jmedchem.9b01312. PMID 31738537. https://orca.cardiff.ac.uk/id/eprint/128150/.
- ↑ "Symptomatic and neurotrophic effects of GABAA receptor positive allosteric modulation in a mouse model of chronic stress". Neuropsychopharmacology 47 (9): 1608–1619. August 2022. doi:10.1038/s41386-022-01360-y. PMID 35701547.
- ↑ "Hippocampal α5-GABAA Receptors Modulate Dopamine Neuron Activity in the Rat Ventral Tegmental Area". Biological Psychiatry Global Open Science 3 (1): 78–86. January 2023. doi:10.1016/j.bpsgos.2021.12.010. PMID 36712569.
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