Chemistry:Flubromazepam
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| Routes of administration | Oral |
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| Elimination half-life | 106 hours |
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| Formula | C15H10BrFN2O |
| Molar mass | 333.160 g·mol−1 |
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Flubromazepam is a benzodiazepine derivative which was first synthesized in 1960,[1] but was never marketed and did not receive any further attention or study until late 2012 when it appeared on the grey market as a novel designer drug.[2][3][4][5][6][7][8]
It is a structural analog of phenazepam in which the chlorine atom has been replaced by a fluorine atom.
An alternate isomer, 5-(2-bromophenyl)-7-fluoro-1,3-dihydro-2H-1,4-benzodiazepin-2-one or "iso-flubromazepam",[9] may have been sold under the same name.[2]
Legal status
United Kingdom
In the UK, flubromazepam has been classified as a Class C drug by the May 2017 amendment to The Misuse of Drugs Act 1971 along with several other designer benzodiazepine drugs.[10]
United States
Flubromazepam, clonazolam, and flubromazolam are Schedule I controlled substances under Virginia State Law.[11]
See also
- List of benzodiazepine designer drugs
- Desmethyletizolam
- Ro07-9749
- SH-I-048A
- Imidazenil (licensed)
- Phenazepam
References
- ↑ "Amino substituted benzophenone oximes and derivatives thereof" US patent 3136815
- ↑ 2.0 2.1 "Detection and identification of the designer benzodiazepine flubromazepam and preliminary data on its metabolism and pharmacokinetics". Journal of Mass Spectrometry 48 (11): 1150–9. November 2013. doi:10.1002/jms.3279. PMID 24259203. Bibcode: 2013JMSp...48.1150M.
- ↑ "Characterization of the designer benzodiazepines pyrazolam and flubromazepam and study on their detectability in human serum and urine samples". Institute of Forensic Medicine, Forensic Toxicology, University Medical Center Freiburg, Freiburg, Germany. https://www.uniklinik-freiburg.de/fileadmin/mediapool/08_institute/rechtsmedizin/pdf/Poster2013/Moosmann_DesignerBenzodiazepine_TIAFT2013.pdf.
- ↑ "ELISA Detection of Phenazepam, Etizolam, Pyrazolam, Flubromazepam, Diclazepam and Delorazepam in Blood Using Immunalysis® Benzodiazepine Kit". Journal of Analytical Toxicology 40 (2): 159–61. March 2016. doi:10.1093/jat/bkv122. PMID 26518230.
- ↑ "Flubromazepam". New Synthetic Drugs Database. 12 November 2023. http://nsddb.eu/substance/375/.
- ↑ "Detectability of designer benzodiazepines in CEDIA, EMIT II Plus, HEIA, and KIMS II immunochemical screening assays". Drug Testing and Analysis 9 (4): 640–645. April 2017. doi:10.1002/dta.2003. PMID 27366870.
- ↑ "Blood concentrations of new designer benzodiazepines in forensic cases". Forensic Science International 268: 35–38. November 2016. doi:10.1016/j.forsciint.2016.09.006. PMID 27685473.
- ↑ "a and plasma protein binding values for benzodiazepines appearing as new psychoactive substances". Drug Testing and Analysis. March 2018. doi:10.1002/dta.2387. PMID 29582576. https://pure.hud.ac.uk/ws/files/13273614/logDpKaPPB_13thMar2018.pdf.
- ↑ "Legal highs: staying on top of the flood of novel psychoactive substances". Therapeutic Advances in Psychopharmacology 5 (2): 97–132. April 2015. doi:10.1177/2045125314559539. PMID 26240749.
- ↑ "The Misuse of Drugs Act 1971 (Amendment) Order 2017". Legislation.gov.uk. http://www.legislation.gov.uk/uksi/2017/634/contents/made.
- ↑ "Administrative Code 18VAC110-20-322. Placement of Chemicals in Schedule I.". Virginia Law. http://law.lis.virginia.gov/admincode/title18/agency110/chapter20/section322/.
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