Chemistry:RO4491533
From HandWiki
Short description: Chemical compound
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| Formula | C24H20F3N3O |
| Molar mass | 423.439 g·mol−1 |
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RO-4491533 is a drug developed by Hoffmann-La Roche which acts as a potent and selective negative allosteric modulator for group II of the metabotropic glutamate receptors (mGluR2/3), being equipotent at mGluR2 and mGluR3 but without activity at other mGluR subtypes. In animal studies, RO-4491533 produced antidepressant effects and reversed the effects of the mGluR2/3 agonist LY-379,268 with similar efficacy but slightly lower potency than the mGluR2/3 antagonist LY-341,495.[1] A number of related compounds are known, with similar effects in vitro and a fairly well characterized structure-activity relationship.[2]
See also
References
- ↑ "Characterization of an mGluR2/3 negative allosteric modulator in rodent models of depression". Journal of Neurogenetics 25 (4): 152–66. December 2011. doi:10.3109/01677063.2011.627485. PMID 22091727.
- ↑ "A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors". The Journal of Pharmacology and Experimental Therapeutics 322 (1): 254–64. July 2007. doi:10.1124/jpet.106.117093. PMID 17416742.
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