Chemistry:Haloxazolam

From HandWiki
Short description: Benzodiazepine
Haloxazolam
Haloxazolam structure.svg
Haloxazolam3d.png
Clinical data
Trade namesSomelin (Japan )
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
Pharmacokinetic data
MetabolismHepatic
ExcretionRenal
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC17H14BrFN2O2
Molar mass377.213 g·mol−1
3D model (JSmol)
 ☒N☑Y (what is this?)

Haloxazolam (marketed in Japan under the brand name Somelin), is a drug which is a benzodiazepine derivative.[1][2][3] It has similar hypnotic properties as the benzodiazepine drugs triazolam, temazepam, and flunitrazepam and as such is indicated for the treatment of insomnia.[4] A study in cats comparing estazolam and haloxazolam found that haloxazolam only affects gamma motor neurons, whereas estazolam affects both alpha and gamma motor neurons.[5]

See also

References

  1. "Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel". Journal of Chromatography B: Biomedical Sciences and Applications 682 (1): 173–8. June 1996. doi:10.1016/0378-4347(96)00121-1. PMID 8832439. 
  2. "Benzodiazepine Names". non-benzodiazepines.org.uk. http://www.non-benzodiazepines.org.uk/benzodiazepine-names.html. 
  3. "Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine". Journal of Analytical Toxicology 23 (1): 54–61. 1999. doi:10.1093/jat/23.1.54. PMID 10022210. 
  4. "Long-, intermediate- and short-acting benzodiazepine effects on human sleep EEG spectra". Psychiatry and Clinical Neurosciences 57 (1): 97–104. February 2003. doi:10.1046/j.1440-1819.2003.01085.x. PMID 12519461. 
  5. "Comparative study on the effects of haloxazolam and estazolam, new sleep inducing drugs, on the alpha- and gamma-motor systems". Japanese Journal of Pharmacology 33 (5): 1017–25. October 1983. doi:10.1254/jjp.33.1017. PMID 6139494.