Chemistry:Mexazolam
From HandWiki
Short description: Benzodiazepam
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| Trade names | Melex, Sedoxil |
| Other names | 13-chloro- 2-(2-chlorophenyl)- 5-methyl- 3-oxa- 6,9-diazatricyclo[8.4.0.02,6] tetradeca- 1(10),11,13-trien- 8-one |
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| Routes of administration | Oral |
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| Metabolism | Liver (CYP3A4) |
| Excretion | Kidney |
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| Formula | C18H16Cl2N2O2 |
| Molar mass | 363.24 g·mol−1 |
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Mexazolam[1] (marketed under the trade names Melex and Sedoxil)[2] is a drug which is a benzodiazepine derivative.[3] Mexazolam has been trialed for anxiety and was found to be effective in alleviating anxiety at one week follow-up. Mexazolam is metabolised via the CYP3A4 pathway. HMG-CoA reductase inhibitors including simvastatin, simvastatin acid, lovastatin, fluvastatin, atorvastatin and cerivastatin inhibit the metabolism of mexazolam,[4] but not the HMG-CoA reductase inhibitor pravastatin.[5][6] Its principal active metabolites are chlorodesmethyldiazepam (also known as chloronordiazepam or delorazepam, trade name Dadumir) and chloroxazepam (also known as lorazepam, trade name Ativan).[7]
See also
References
- ↑ DE Patent 1954065
- ↑ "Benzodiazepine Names". non-benzodiazepines.org.uk. http://www.non-benzodiazepines.org.uk/benzodiazepine-names.html.
- ↑ "Kinetics and mechanism of the acid-base equilibrium of mexazolam and comparison with those of other commercial benzodiazepinooxazole drugs". Chemical & Pharmaceutical Bulletin 35 (9): 3831–3837. September 1987. doi:10.1248/cpb.35.3831. PMID 2893667.
- ↑ "The effects of concurrent atorvastatin therapy on the pharmacokinetics of intravenous midazolam". Anaesthesia 58 (9): 899–904. September 2003. doi:10.1046/j.1365-2044.2003.03339.x. PMID 12911366.
- ↑ "Sex difference in inhibition of in vitro mexazolam metabolism by various 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors in rat liver microsomes". Drug Metabolism and Disposition 30 (8): 904–910. August 2002. doi:10.1124/dmd.30.8.904. PMID 12124308.
- ↑ "A comparison of the effects of 3-hydroxy-3-methylglutaryl-coenzyme a (HMG-CoA) reductase inhibitors on the CYP3A4-dependent oxidation of mexazolam in vitro". Drug Metabolism and Disposition 29 (3): 282–288. March 2001. PMID 11181496. http://dmd.aspetjournals.org/cgi/content/full/29/3/282.
- ↑ "Mexazolam: clinical efficacy and tolerability in the treatment of anxiety". Neurology and Therapy 3 (1): 1–14. June 2014. doi:10.1007/s40120-014-0016-7. PMID 26000220.
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