Chemistry:SH-I-048A
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Short description: Chemical compound
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| Formula | C16H12BrFN2O |
| Molar mass | 347.187 g·mol−1 |
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SH-I-048A (SH-i-048A) is a benzodiazepine derivative related in structure to compounds such as flubromazepam and meclonazepam. SH-I-048A is described as a non subtype selective superagonist at the benzodiazepine site of GABAA receptors,[1] with a binding affinity of 0.77nM at the α1 subtype, 0.17nM at α2, 0.38nM at α3 and 0.11nM at α5.[2] It has been used to study the functional differences between the different subtypes of the GABAA receptor.[3][4]
See also
References
- ↑ "Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects". Brain Research 1554: 36–48. 2014. doi:10.1016/j.brainres.2014.01.036. PMID 24472579.
- ↑ "A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model". International Journal of Medicinal Chemistry 2015: 430248. 2015. doi:10.1155/2015/430248. PMID 26682068.
- ↑ "Delayed Behavioral Effects of SH–I–048A, a Novel Nonselective Positive Modulator of Gabaa Receptors, After Peripheral Nerve Injury in Rats.". Acta Veterinaria 64 (2): 189–99. June 2014. doi:10.2478/acve-2014-0018.
- ↑ "Different Benzodiazepines Bind With Distinct Binding Modes to GABAA Receptors". ACS Chemical Biology 13 (8): 2033–2039. August 2018. doi:10.1021/acschembio.8b00144. PMID 29767950.
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