Chemistry:Arfendazam

Short description: Chemical compound

Arfendazam

Clinical data
ATC code	none
Identifiers
IUPAC name Ethyl 7-chloro-4-oxo-5-phenyl-2,3-dihydro-1,5-benzodiazepine-1-carboxylate
CAS Number	37669-57-1 Y
PubChem CID	65803
ChemSpider	59219 Y
UNII	P37G7BTX8V
ChEMBL	ChEMBL2104444 N
Chemical and physical data
Formula	C18H17ClN2O3
Molar mass	344.792 g·mol−1
3D model (JSmol)	Interactive image
SMILES ClC1=CC2=C(C=C1)N(CCC(N2C3=CC=CC=C3)=O)C(OCC)=O
InChI InChI=1S/C18H17ClN2O3/c1-2-24-18(23)20-11-10-17(22)21(14-6-4-3-5-7-14)16-12-13(19)8-9-15(16)20/h3-9,12H,2,10-11H2,1H3 Y Key:NXJWVCHVPUCWJS-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Arfendazam (INN) is a drug which is a benzodiazepine derivative. Arfendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring, and so is most closely related to other 1,5-benzodiazepines such as clobazam.

Arfendazam has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives, but is a partial agonist at GABA_A receptors, so the sedative effects are relatively mild and it produces muscle relaxant effects only at very high doses.

Arfendazam produces an active metabolite lofendazam, which is thought to be responsible for part of its effects.

See also

• Benzodiazepine