Chemistry:Quazinone
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Short description: Chemical compound
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| Other names | Ro 13-6438 |
| Routes of administration | Oral |
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| Formula | C11H10ClN3O |
| Molar mass | 235.67 g·mol−1 |
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Quazinone (Dozonone) is a cardiotonic and vasodilator drug which was developed and marketed in the 1980s for the treatment of heart disease.[1][2][3][4][5] It acts as a selective PDE3 inhibitor.[6][7] It is no longer available.[1]
See also
References
- ↑ 1.0 1.1 David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 978-0-412-46630-4. https://books.google.com/books?id=A0THacd46ZsC&q=Quazinone&pg=PA1716.
- ↑ "Cardiovascular profile of Ro 13-6438, a novel positive inotropic agent with vasodilating properties". Journal of Cardiovascular Pharmacology 6 (3): 511–9. 1984. doi:10.1097/00005344-198405000-00021. PMID 6202980.
- ↑ "Studies on the mechanism of positive inotropic activity of Ro 13-6438, a structurally novel cardiotonic agent with vasodilating properties". Journal of Cardiovascular Pharmacology 6 (3): 520–30. 1984. doi:10.1097/00005344-198405000-00022. PMID 6202981.
- ↑ "Dose-response following single administrations of a new cardiac performance enhancer RO 13-6438 in normal volunteers". Journal of Cardiovascular Pharmacology 7 (1): 86–90. 1985. doi:10.1097/00005344-198501000-00014. PMID 2580156.
- ↑ "RO13-6438, a new inotrope-vasodilator: systemic and coronary hemodynamic effects in congestive heart failure". The American Journal of Cardiology 55 (13 Pt 1): 1539–44. June 1985. doi:10.1016/0002-9149(85)90969-5. PMID 4003296.
- ↑ "Inhibition of platelet-derived growth factor-induced mitogenesis by phosphodiesterase 3 inhibitors: role of protein kinase A in vascular smooth muscle cell mitogenesis". Biochemical Pharmacology 60 (3): 381–7. August 2000. doi:10.1016/S0006-2952(00)00328-2. PMID 10856433.
- ↑ "Phosphodiesterase 4-dependent regulation of cyclic AMP levels and leukotriene B4 biosynthesis in human polymorphonuclear leukocytes". European Journal of Pharmacology 367 (2–3): 343–50. February 1999. doi:10.1016/S0014-2999(98)00987-X. PMID 10079010.
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