Chemistry:Xamoterol
Xamoterol, sold under the brand names Corwin, Carwin, Corwil, and Xamtol among others, is a cardiac stimulant which is used in the treatment of heart failure.[1] It acts as a selective partial agonist of the β1-adrenergic receptor with around 50% intrinsic sympathomimetic activity (ISA) (i.e., intrinsic activity).[2][3][4][1] The drug has no significant β2-adrenergic receptor agonistic activity.[5] Xamoterol provides cardiac stimulation at rest but acts as a blocker during exercise.[6] It is taken by mouth.[2]
Xamoterol is not available in the United States.[7][8] It is marketed in the United Kingdom, Austria, Belgium, and Luxembourg.[8]
Xamoterol is a hydrophilic compound with a predicted log P of -0.31 to -1.11.[9][10][11][12] Due to its hydrophilicity, xamoterol does not cross the blood–brain barrier and has no central nervous system effects.[12] Hence, it is a peripherally selective drug.[12]
See also
References
- ↑ 1.0 1.1 "Xamoterol, a beta 1-adrenoceptor partial agonist: review of the clinical efficacy in heart failure". British Journal of Clinical Pharmacology 28 (Suppl 1): 23S–30S. 1989. doi:10.1111/j.1365-2125.1989.tb03570.x. PMID 2572251.
- ↑ 2.0 2.1 Cite error: Invalid
<ref>tag; no text was provided for refs namedFurlongBrogden1988 - ↑ "The management of heart failure and the scope for new therapies: what role for xamoterol?". Br J Clin Pharmacol 28 Suppl 1 (Suppl 1): 59S–64S. 1989. doi:10.1111/j.1365-2125.1989.tb03574.x. PMID 2572256.
- ↑ "The xamoterol experience in the treatment of heart failure". Am J Cardiol 71 (9): 61C–64C. March 1993. doi:10.1016/0002-9149(93)90088-t. PMID 8465800.
- ↑ "Xamoterol: Uses, Interactions, Mechanism of Action". 23 June 2017. https://go.drugbank.com/drugs/DB13781.
- ↑ Pharmacology (5th ed.). Edinburgh; New York: Churchill Livingstone. 1999. p. 163. ISBN 0443059748.
- ↑ "Drugs@FDA: FDA-Approved Drugs". https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm.
- ↑ 8.0 8.1 Schweizerischer Apotheker-Verein (2000). Index Nominum 2000: International Drug Directory. Medpharm Scientific Publishers. p. 1099. ISBN 978-3-88763-075-1. https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA1099. Retrieved 23 July 2024.
- ↑ "Xamoterol". https://pubchem.ncbi.nlm.nih.gov/compound/155774.
- ↑ "Xamoterol: Uses, Interactions, Mechanism of Action". 23 June 2017. https://go.drugbank.com/drugs/DB13781.
- ↑ "Xamoterol [USAN:BAN:INN"]. 21 July 2022. https://www.chemspider.com/Chemical-Structure.137213.html.
- ↑ 12.0 12.1 12.2 "Effects of xamoterol, a beta 1 adrenoceptor partial agonist, in patients with ischaemic dysfunction of the left ventricle". Br Heart J 62 (5): 335–341. November 1989. doi:10.1136/hrt.62.5.335. PMID 2574049.
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