Chemistry:Etilefrine
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| Other names | (2-ethylamino-1-(3'-hydroxy-phenyl)ethanol |
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| Formula | C10H15NO2 |
| Molar mass | 181.235 g·mol−1 |
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| Chirality | Racemic mixture |
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Etilefrine is a cardiac stimulant used as an antihypotensive. It is a sympathomimetic amine of the 3-hydroxy-phenylethanolamine series used in treating orthostatic hypotension of neurological, cardiovascular, endocrine or metabolic origin. Intravenous infusion of this compound increases cardiac output, stroke volume, venous return and blood pressure in man and experimental animals, suggesting stimulation of both α and β adrenergic receptors.[1][2][3][4][5] However, in vitro studies indicate that etilefrine has a much higher affinity for β1 (cardiac) than for β2 adrenoreceptors.[6]
Intravenous etilefrine increases the pulse rate, cardiac output, stroke volume, central venous pressure and mean arterial pressure of healthy individuals. Peripheral vascular resistance falls during the infusion of 1–8 mg etilefrine but begins to rise at higher dosage. Marked falls in pulse rate, cardiac output, stroke volume and peripheral bloodflow, accompanied by rises in mean arterial pressure, occur when etilefrine is infused after administration of intravenous propranolol 2,5 mg. These findings indicate that etilefrine has both β1 and α1 adrenergic effects in man.
References
- ↑ "[On the circulatory action of depot-Effortil in patients with hypotonic regulation circulator disorders]" (in German). Die Medizinische Welt 32: 1824–7. August 1965. PMID 5320529.
- ↑ "Comparative effects of acetylcholine, butyl-nor-synephrine (Vasculat), noradrenaline, and ethyl-adrainol (Effonti) on resistance, capacitance, and precapillary sphincter vessels and capillary filtration in cat skeletal muscle". Angiologica 3 (2): 77–99. 1966. doi:10.1159/000157650. PMID 4380206.
- ↑ "Positive inotrope Wirkung von Etilefrinhydrochlorid (EffortilR)". Kardiol 586: 1. 1973.
- ↑ "Experimentelle Untersuchungen zur Beeinflussung der Hämodynamik in tiefer Halothannarkose durch Dopamin, Glucagon, Effortil, Noradrenalin und Dextran". Der Anaesthesist 22: 8–15. 1973.
- ↑ "Algunos effectos circulatorios de la m− oxifenil etanol etilmaina y sus modificaciones por el bloqueo α y β adrenergico.". Arch. Inst. Cardiol. (Mexico) 43: 279–287. 1973.
- ↑ "A comparison of the effects of noradrenaline, adrenaline and some phenylephrine derivatives on alpha-, beta- and beta- adrenergic receptors". South African Medical Journal = Suid-Afrikaanse Tydskrif vir Geneeskunde 45 (10): 265–7. March 1971. PMID 4396765.
External links
- "Etilefrine". PubChem. https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3306.
- "Etilefrine". Kegg. http://www.genome.jp/dbget-bin/www_bget?dr:D07931.
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