Chemistry:Dimetofrine
Dimetofrine (INN), also known as dimethophrine or dimetophrine and sold under the brand names Dovida, Pressamina, and Superten, is a medication described as a sympathomimetic, vasoconstrictor, and cardiac stimulant.[1][2][3] It is said to be similarly or less effective than midodrine in the treatment of orthostatic hypotension and shows substantially lower potency.[4][5]
The drug is a selective α1-adrenergic receptor agonist[6] but is also said to have β-adrenergic receptor agonist activity.[5] It is a substituted phenethylamine and is also known as 3,5-dimethoxy-4,β-dihydroxy-N-methylphenethylamine.[1] Its chemical structure is similar to that of desglymidodrine (3,6-dimethoxy-β-hydroxyphenethylamine), the active metabolite of midodrine.[4]
Dimetofrine remained marketed only in Italy in 2000.[2]
References
- ↑ 1.0 1.1 Elks, J. (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 443. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA443. Retrieved 31 August 2024.
- ↑ 2.0 2.1 Schweizerischer Apotheker-Verein (2000). Index Nominum 2000: International Drug Directory. Index nominum. Medpharm Scientific Publishers. p. 352. ISBN 978-3-88763-075-1. https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA352. Retrieved 31 August 2024.
- ↑ "Double-blind clinical evaluation of dimetophrine in chronically reduced arterial tension". Curr Med Res Opin 9 (2): 78–85. 1984. doi:10.1185/03007998409109563. PMID 6399891.
- ↑ 4.0 4.1 "Midodrine. A review of its therapeutic use in the management of orthostatic hypotension". Drugs Aging 12 (1): 76–86. January 1998. doi:10.2165/00002512-199812010-00007. PMID 9467688.
- ↑ 5.0 5.1 "Midodrine. A review of its pharmacological properties and therapeutic use in orthostatic hypotension and secondary hypotensive disorders". Drugs 38 (5): 757–777. November 1989. doi:10.2165/00003495-198938050-00004. PMID 2480881.
- ↑ "Controlled clinical investigation of dimetophrine versus midodrine in the management of moderately decreased arterial blood pressure". Curr Med Res Opin 9 (4): 265–274. 1984. doi:10.1185/03007998409109590. PMID 6210180.
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