Biology:Zinc transporter 1
From HandWiki
Short description: Protein found in humans
 Generic protein structure example |
Zinc transporter 1 is a protein which in humans is encoded by the SLC30A1 gene.[1][2]
Function
SLC30A1 modulates zinc permeation through the L-type calcium channel. SLC30A1 downregulates not only Zn++ influx, but also Ca++ influx, thereby protecting cells from the effects of excessive cation permeation.[3]
See also
References
- ↑ "Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc". The EMBO Journal 14 (4): 639–49. February 1995. doi:10.1002/j.1460-2075.1995.tb07042.x. PMID 7882967.
- ↑ "In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression". BMC Genomics 5 (1): 32. May 2004. doi:10.1186/1471-2164-5-32. PMID 15154973.
- ↑ "A role for ZnT-1 in regulating cellular cation influx". Biochemical and Biophysical Research Communications 323 (4): 1145–50. October 2004. doi:10.1016/j.bbrc.2004.08.211. PMID 15451416.
Further reading
- "Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.". Eur. Urol. 57 (2): 283–292. 2009. doi:10.1016/j.eururo.2009.08.001. PMID 19692168.
- "Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain.". Brain Res. Bull. 77 (1): 55–60. 2008. doi:10.1016/j.brainresbull.2008.03.014. PMID 18639746.
- "Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease.". Neurotoxicity Research 7 (4): 265–71. 2005. doi:10.1007/BF03033884. PMID 16179263.
- "Regulation of zinc transporters by dietary flaxseed lignan in human breast cancer xenografts.". Mol. Biol. Rep. 35 (4): 595–600. 2008. doi:10.1007/s11033-007-9129-8. PMID 17786585.
- "Zinc and metallothionein levels and expression of zinc transporters in androgen-independent subline of LNCaP cells.". J. Androl. 25 (1): 154–61. 2004. doi:10.1002/j.1939-4640.2004.tb02771.x. PMID 14662799.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses.". J. Exp. Med. 205 (1): 35–42. 2008. doi:10.1084/jem.20071311. PMID 18158319.
- "Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9.". J. Leukoc. Biol. 83 (2): 368–80. 2008. doi:10.1189/jlb.0307148. PMID 17971500.
- "PTEN identified as important risk factor of chronic obstructive pulmonary disease.". Respiratory Medicine 103 (12): 1866–1870. 2009. doi:10.1016/j.rmed.2009.06.016. PMID 19625176.
- "Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.". Carcinogenesis 29 (10): 1938–43. 2008. doi:10.1093/carcin/bgn178. PMID 18676680.
- "Correlation between atrial ZnT-1 expression and atrial fibrillation in humans: a pilot study.". J. Cardiovasc. Electrophysiol. 19 (2): 157–64. 2008. doi:10.1111/j.1540-8167.2007.01008.x. PMID 17971132.
- "Toward a confocal subcellular atlas of the human proteome.". Mol. Cell. Proteomics 7 (3): 499–508. 2008. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.
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