Chemistry:BAY 60–6583
From HandWiki
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| Names | |
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| Preferred IUPAC name
2-({6-Amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl}sulfanyl)acetamide | |
| Other names
BAY 60–6583
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| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
PubChem CID
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| UNII | |
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| Properties | |
| C19H17N5O2S | |
| Molar mass | 379.435 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Tracking categories (test):
BAY 60–6583 is a selective adenosine A2B receptor agonist.[1] It has been shown to provide protection from ischemia (lack of oxygen due to blocked blood supply) in both the heart and kidney of test animals,[2][3] and has also been shown to be beneficial in treatment of acute lung and brain injury,[4][5] as well as claimed anti-aging and anti-obesity effects,[6] showing a range of potential applications for selective A2B agonists.
References
- ↑ "Recent improvements in the development of A(2B) adenosine receptor agonists". Purinergic Signalling 4 (4): 287–303. December 2008. doi:10.1007/s11302-008-9097-z. PMID 18443746.
- ↑ "Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors". Circulation 115 (12): 1581–90. March 2007. doi:10.1161/CIRCULATIONAHA.106.669697. PMID 17353435.
- ↑ "The reno-vascular A2B adenosine receptor protects the kidney from ischemia". PLOS Medicine 5 (6): e137. June 2008. doi:10.1371/journal.pmed.0050137. PMID 18578565.
- ↑ "A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice". The Journal of Clinical Investigation 118 (10): 3301–15. October 2008. doi:10.1172/JCI34203. PMID 18787641.
- ↑ "Inhibition of tPA-induced hemorrhagic transformation involves adenosine A2b receptor activation after cerebral ischemia". Neurobiology of Disease 108: 173–182. December 2017. doi:10.1016/j.nbd.2017.08.011. PMID 28830843.
- ↑ "Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity". Cell Metabolism 32 (1): 56–70.e7. July 2020. doi:10.1016/j.cmet.2020.06.006. PMID 32589947.
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