Chemistry:Dilazep
From HandWiki
Dilazep is a vasodilator that acts as an adenosine reuptake inhibitor.[1][2]
It is used for the treatment of cardiopathy and renal disorders.[3]
Synthesis
The reaction of bis(3-hydroxypropyl)ethylene diamine (1) with 1-bromo-3-chloropropane (2) gives the homopiperazine derivative 3. Esterification by reaction with 3,4,5-trimethoxybenzoyl chloride (4) completes the synthesis of dilazep (5).[4][5][6]
See also
- Hexobendine, a drug with similar chemical structure
References
- ↑ "Dilazep, an antiplatelet agent, inhibits tissue factor expression in endothelial cells and monocytes". Blood 90 (6): 2345–56. September 1997. doi:10.1182/blood.V90.6.2345. PMID 9310485.
- ↑ PubChem. "Dilazep" (in en). https://pubchem.ncbi.nlm.nih.gov/compound/3074.
- ↑ "Pharmaceuticals". Kowa Company Ltd.. http://www.kowa.co.jp/eng/company/division/pharmaceutic.htm.
- ↑ Thieme
- ↑ GB1107470 idem Herbert Arnold, Kurt Pahls, Rolf Rebling,Norbert Brock, Hans-Dieter Lenke, U.S. Patent 3,532,685 (1970 to Asta Werke Ag Chem Fab)
- ↑ "Über pharmakodynamisch wirksame 3,4,5-Trimethoxybenzoate und verwandte Ester von symmetrischen Bis-hydroxyalkylpiperazinen und-dialkylpolymethylendiaminen". Monatshefte für Chemie 95 (3): 922–941. 1964. doi:10.1007/BF00908805.
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