Chemistry:Tracazolate
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| Routes of administration | By mouth |
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| Formula | C16H24N4O2 |
| Molar mass | 304.394 g·mol−1 |
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Tracazolate (ICI-136,753) is an anxiolytic drug which is used in scientific research. It is a pyrazolopyridine derivative, most closely related to pyrazolopyrimidine drugs such as zaleplon, and is one of a structurally diverse group of drugs known as the nonbenzodiazepines which act at the same receptor targets as benzodiazepines but have distinct chemical structures.[1]
Tracazolate has primarily anxiolytic and anticonvulsant effects, with sedative and muscle relaxant effects only appearing at higher doses.[2] It has a unique receptor binding profile involving allosteric modulation of several GABAA receptor subtypes, being selective for GABAA receptors containing α1 and β3 subunits, but exhibiting different effects depending on the third type of subunit making up the receptor complex.[3]
See also
References
- ↑ "Pharmacology of pyrazolopyridines". Pharmacology, Biochemistry, and Behavior 23 (4): 675–80. October 1985. doi:10.1016/0091-3057(85)90436-8. PMID 2866547.
- ↑ "Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic agent". European Journal of Pharmacology 78 (3): 323–33. March 1982. doi:10.1016/0014-2999(82)90034-6. PMID 6121711.
- ↑ "Tracazolate reveals a novel type of allosteric interaction with recombinant gamma-aminobutyric acid(A) receptors". Molecular Pharmacology 61 (4): 861–9. April 2002. doi:10.1124/mol.61.4.861. PMID 11901225.
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