Chemistry:MRS-1706
From HandWiki
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| Names | |
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| IUPAC name
N-(4-Acetylphenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]acetamide
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| Other names
MRS 1706
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| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
| MeSH | C496145 |
PubChem CID
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| UNII | |
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| Properties | |
| C27H29N5O5 | |
| Molar mass | 503.56 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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| Infobox references | |
Tracking categories (test):
MRS-1706 is a selective inverse agonist for the adenosine A2B receptor.[1] It inhibits release of interleukins and has an antiinflammatory effect.[2][3]
References
- ↑ "ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor". The Journal of Pharmacology and Experimental Therapeutics 320 (2): 637–45. February 2007. doi:10.1124/jpet.106.111203. PMID 17077318.
- ↑ "Local stimulation of the adenosine A2B receptors induces an increased release of IL-6 in mouse striatum: an in vivo microdialysis study". Journal of Neurochemistry 105 (3): 904–9. May 2008. doi:10.1111/j.1471-4159.2007.05191.x. PMID 18088370.
- ↑ "Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells". Journal of Immunology 180 (11): 7212–20. June 2008. doi:10.4049/jimmunol.180.11.7212. PMID 18490720.
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