Chemistry:Istradefylline

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Short description: Chemical compound
Istradefylline
Istradefylline structure.svg
Clinical data
Trade namesNouriast, Nourianz
Other namesKW-6002
AHFS/Drugs.comMonograph
License data
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding98%
MetabolismMainly CYP1A1, CYP3A4, and CYP3A5
Elimination half-life64–69 hrs
Excretion68% faeces, 18% urine
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC20H24N4O4
Molar mass384.436 g·mol−1
3D model (JSmol)
  (verify)

Istradefylline, sold under the brand name Nourianz, is a medication used as an add-on treatment to levodopa/carbidopa in adults with Parkinson's disease (PD) experiencing "off" episodes.[2][3][4] Istradefylline reduces "off" periods resulting from long-term treatment with the antiparkinson drug levodopa.[2] An "off" episode is a time when a patient's medications are not working well, causing an increase in PD symptoms, such as tremor and difficulty walking.[2]

Relatively common side effects include involuntary muscle movements (dyskinesia), constipation, hallucinations, dizziness and, much like its parent molecule caffeine, nausea and sleeplessness.[2]

The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication.[5]

Mechanism of action

Istradefylline is a selective antagonist at the adenosine A2A receptor (A2AR), but the precise mechanism by which it exerts its therapeutic effect in Parkinson's disease is unknown.[6] However, it is known that dimers of these receptors form heterotetramers with the dimers of dopamine D2 receptors (D2R) within striatum. Adenosine acts as an endogenous A2AR agonist, but also as a negative allosteric modulator (NAM) within these tetramers towards D2Rs, thus inhibiting the D2R mediated effects of dopamine, an endogenous D2R agonist. Istradefylline is believed to bind an A2AR within an A2AR-D2R-tetramer and function as a NAM towards the other A2AR (instead of D2R), thus inhibiting the effects of adenosine and enhancing the movement (locomotion) promoting effects exerted by dopamine via D2R. However, at high istradefylline concentration, it causes locomotion depression akin to caffeine (which is a broad-spectrum adenosine receptor antagonist), and might do so by displacing adenosine, and working as a NAM towards D2R (instead of A2AR).[7]

Adverse effects

The adverse effects of Istradefylline have only been studied in the context of treating "off" episodes in Parkinson's disease. The most common adverse effects of Istradefylline in clinical trials are dyskinesia exacerbation (roughly 9% increase relative to placebo), malaise, and nasopharyngitis (common cold).[8][9]

History

It was first approved in Japan in 2013.[10]

The effectiveness of Nourianz in treating "off" episodes in patients with Parkinson's disease who are already being treated with levodopa/carbidopa was shown in four 12-week placebo-controlled clinical studies that included a total of 1,143 participants. In all four studies, people treated with Nourianz experienced a statistically significant decrease from baseline in daily "off" time compared to patients receiving a placebo.[2][3]

It was approved for medical use in the United States in 2019.[2][3][11] and approval was granted to Kyowa Kirin, Inc.[2]

References

  1. ↑ "Nourianz- istradefylline tablet, film coated". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a7d008cb-b273-4049-a5d2-9c6902910d58. 
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 "FDA approves new add-on drug to treat off episodes in adults with Parkinson's disease". U.S. Food and Drug Administration (FDA) (Press release). 27 August 2019. Archived from the original on 4 September 2019. Retrieved 29 August 2019. This article incorporates text from this source, which is in the public domain.
  3. ↑ 3.0 3.1 3.2 "Drug Trials Snapshots: Nourianz". 23 September 2019. https://www.fda.gov/drugs/drug-trials-snapshots-nourianz.  This article incorporates text from this source, which is in the public domain.
  4. ↑ "Contemporary Options for the Management of Motor Complications in Parkinson's Disease: Updated Clinical Review". Drugs 79 (6): 593–608. April 2019. doi:10.1007/s40265-019-01098-w. PMID 30905034. 
  5. ↑ "New Drug Therapy Approvals 2019". 31 December 2019. https://www.fda.gov/drugs/new-drugs-fda-cders-new-molecular-entities-and-new-therapeutic-biological-products/new-drug-therapy-approvals-2019.  This article incorporates text from this source, which is in the public domain.
  6. ↑ "Mechanism of Action". http://www.nourianzhcp.com/mechanism-of-action. 
  7. ↑ "New Developments on the Adenosine Mechanisms of the Central Effects of Caffeine and Their Implications for Neuropsychiatric Disorders". Journal of Caffeine and Adenosine Research 8 (4): 121–131. December 2018. doi:10.1089/caff.2018.0017. PMID 30596206. 
  8. ↑ "Influence of istradefylline on non-motor symptoms of Parkinson's disease: A subanalysis of a 1-year observational study in Japan (J-FIRST)". Parkinsonism & Related Disorders 91: 115–120. October 2021. doi:10.1016/j.parkreldis.2021.09.015. PMID 34583302. 
  9. ↑ "A long-term study of istradefylline safety and efficacy in patients with Parkinson disease". Clinical Neuropharmacology 38 (2): 41–46. 2015. doi:10.1097/WNF.0000000000000073. PMID 25768849. 
  10. ↑ "Istradefylline: first global approval". Drugs 73 (8): 875–882. June 2013. doi:10.1007/s40265-013-0066-7. PMID 23700273. 
  11. ↑ "Drug Approval Package: Nourianz". https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/022075Orig1s000TOC.cfm. 

External links



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