Chemistry:Propazepine
From HandWiki
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| Names | |
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| Preferred IUPAC name
3-(6,11-Dihydro-5H-dibenzo[b,e]azepin-5-yl)-N,N-dimethylpropan-1-amine | |
| Other names
Prazepine, Proazepine
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| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
PubChem CID
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| UNII | |
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| Properties | |
| C19H24N2 | |
| Molar mass | 280.415 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Propazepine is a tricyclic antidepressant (TCA).[1] Propazepine is sometimes confused with imipramine, which has the central ring nitrogen in a different location.[1] Prazepine is the International nonproprietary name of this compound.[2] Prazepine is also reported to be one of the many synonyms of imipramine.[3] Propazepine can be synthesized chemically.[4][5] Propazepine appears to never have actually been used as a tricyclic antidepressant outside of initial medical tests;[citation needed] therefore, there is little information about it.
References
- ↑ 1.0 1.1 Benešová, O.; Bohdanecký, Z.; Votava, Z. (1962). "Electrophysiological comparison of the action of imipramine and propazepine". Psychopharmacologia 3 (6): 423–431. doi:10.1007/BF00411159. PMID 13967414.
- ↑ "Propazepine – C19H24N2". Pubchem. https://pubchem.ncbi.nlm.nih.gov/compound/299322#section=Top.
- ↑ "Imipramine – C19H24N2". ChemSpider. http://www.chemspider.com/Chemical-Structure.3568.html.
- ↑ Werner, L. H.; Ricca, S.; Mohacsi, E.; Rossi, A.; Arya, V. P. (1965). "Derivatives of Morphanthridine". Journal of Medicinal Chemistry 8: 74–80. doi:10.1021/jm00325a016. PMID 14287270.
- ↑ Jílek, J. O.; Pomykáček, J.; Svátek, E.; Seidlová, V.; Rajšner, M.; Pelz, K.; Hoch, B.; Protiva, M. (1965). "Neurotrope und psychotrope substanzen II. Morphanthridin und derivate. Neue synthese des propazepins" (in Czech). Collection of Czechoslovak Chemical Communications 30 (2): 445–462. doi:10.1135/cccc19650445.
Further reading
- Vojtechovsky, M; Safratova, V; Soukupova, B (1970). "The influence of propazepine on learning and memory in healthy volunteers and in patients with slight chronic brain syndrome" (in Czech). Activitas Nervosa Superior 12 (3): 251–2. ISSN 0001-7604. PMID 5457443.
- Rysánek, K; Vítek, V; Svehla, C (1965). "Serotonin level in human and animal thrombocytes after imipramine and propazepine administration" (in Czech). Activitas Nervosa Superior 7 (3): 261–2. ISSN 0001-7604. PMID 5882104.
- Souskova, M; Votava, Z; Roth, Z (1964). "Effect of Iproniazid, Propazepine, Reserpine and Their Combinations on the Orientation Reaction and Conditioned Defense Reaction in Rats" (in Czech). Activitas Nervosa Superior 6: 258–67. ISSN 0001-7604. PMID 14179381.
- Vinarova, M; Nahunek, K; Vencovsky, E; Bast Ecky, J; Hadlik, J (1962). "Blind comparison of clinical effects of Imipramine and Propazepine" (in Czech). Activitas Nervosa Superior 4: 227–8. ISSN 0001-7604. PMID 13926058.
- Souskova, M; Votava, Z (1962). "Comparative studies on the effect of Imipramine and Propazepine by a conditioned reflex method in rats" (in Czech). Activitas Nervosa Superior 4: 218–9. ISSN 0001-7604. PMID 13915453.
- Benesova, O; Bohdanecky, Z; Votava, Z (1962). "Comparative studies on the effect of Imipramine and Propazepine by electrophysiological methods on animals with implanted electrodes" (in Czech). Activitas Nervosa Superior 4: 215–6. ISSN 0001-7604. PMID 13867184.
- Metysova, J; Votava, Z (1961). "Comparison of pharmacological properties of propazepine and imipramine" (in Czech). Activitas Nervosa Superior 3: 227. ISSN 0001-7604. PMID 14473038.
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