Chemistry:Pipofezine

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Short description: Chemical compound
Pipofezine
Pipofezine.png
Clinical data
Trade namesAzafen, Azaphen
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC16H19N5O
Molar mass297.362 g·mol−1

Pipofezine, sold under the brand name Azafen or Azaphen, is a tricyclic antidepressant approved in Russia for the treatment of depression.[1][2][3][4] It was introduced in the late 1960s and is still used today.[5][6]

Pipofezine has been shown to act as a potent inhibitor of the reuptake of serotonin.[7][8] In addition to its antidepressant action, pipofezine has sedative effects as well, suggesting antihistamine activity.[9] Other properties such as anticholinergic or antiadrenergic actions are less clear but are likely.[citation needed]

See also

References

  1. ↑ "Comparison of antidepressant effects of azafan, tianeptine, and paroxetine". Bulletin of Experimental Biology and Medicine 148 (1): 54–56. July 2009. doi:10.1007/s10517-009-0638-4. PMID 19902096. 
  2. ↑ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 843. ISBN 3-88763-075-0. https://google.co.in/books/edition/_/5GpcTQD_L2oC?hl=en&gbpv=1&dq=pipofezine&pg=PA843. 
  3. ↑ European Drug Index, 4th Edition. Boca Raton: CRC Press. 1998. p. 126. ISBN 3-7692-2114-1. https://books.google.com/books?id=GCBiEAAAQBAJ&dq=Pipofezine&pg=PA126. 
  4. ↑ Annual Reports in Medicinal Chemistry, Volume V44. Boston: Academic Press. 2009. p. 16. ISBN 978-0-12-374766-2. https://books.google.com/books?id=dBGM4WSV_YEC&dq=azaphen&pg=PA16. 
  5. ↑ "[The pharmacologic properties and therapeutic effectiveness of the new antidepressant preparation Azaphen]" (in ru). Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova 69 (8): 1234–1238. 1969. PMID 5392529. 
  6. ↑ "[Azaphen: a return to clinical practice]" (in ru). Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova 105 (10): 55–56. 2005. PMID 16281382. 
  7. ↑ "[Atypical antidepressants: effect on synaptosomal uptake of serotonin and GABA]" (in ru). Biulleten' Eksperimental'noi Biologii I Meditsiny 92 (11): 564–566. November 1981. PMID 7198493. 
  8. ↑ "Behavioural and neurochemical studies of the action of atypical antidepressants". Acta Physiologica et Pharmacologica Bulgarica 9 (3): 3–10. 1983. PMID 6142583. 
  9. ↑ Annual Reports in Medicinal Chemistry, Volume V44. Boston: Academic Press. 2009. ISBN 978-0-12-374766-2. https://books.google.com/books?id=dBGM4WSV_YEC&q=azaphen&pg=PA16. 



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