Chemistry:Eprobemide
From HandWiki
Short description: Chemical compound
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| Trade names | Befol (Russia ) |
| Other names | Befol |
| Routes of administration | Oral |
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| Formula | C14H19ClN2O2 |
| Molar mass | 282.77 g·mol−1 |
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Eprobemide (INN) is a pharmaceutical drug that was used as an antidepressant in Russia (under the brand name Бефол/Befol).[1] It is a non-competitive reversible inhibitor of monoamine oxidase A[2][3] that exhibits selective action on serotonin deamination.[4] Eprobemide differs from moclobemide only in the linker that connects the morpholine fragment with the chlorobenzamide — moclobemide has two carbon atoms while eprobemide has three. Its registration was cancelled on December 30, 2003.[5]
References
- ↑ Dictionary of Pharmacological Agents. 3. 1996. p. 811. ISBN 978-0412466304.
- ↑ "[The action of befol and its derivatives on monoamine oxidase of different origins]". Biulleten' Eksperimental'noi Biologii I Meditsiny 111 (3): 279–80. March 1991. PMID 2054504.
- ↑ "Antidepressant Befol Synthesized Via Interaction of 4-Chloro-N-(3-chloropropyl)benzamide with Morpholine". Pharmaceutical Chemistry Journal. 0091-150X 38 (7): 381–384. 2004-07-01. doi:10.1023/B:PHAC.0000048439.38383.5f.
- ↑ "Eprobemide". ChemIDplus. https://chem.nlm.nih.gov/chemidplus/rn/87940-60-1.
- ↑ "Befol" (in Russian). 4DOKTOR.RU Drug Information Handbook. http://www.4doktor.ru/default.aspx?drugid=35741.
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