Chemistry:Dimetacrine

From HandWiki
Short description: Chemical compound
Dimetacrine
Skeletal formula of dimetacrine
Ball-and-stick model of the dimetacrine molecule
Clinical data
Trade namesIstonil, Istonyl, Linostil, Miroistonil
Routes of
administration		Oral
ATC code
Legal status
Legal status
  • BR: Class C1 (Other controlled substances)
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
Chemical and physical data
FormulaC20H26N2
Molar mass294.442 g·mol−1
3D model (JSmol)

Dimetacrine (brand names Istonil, Istonyl, Linostil, Miroistonil), also known as dimethacrine and acripramine, is a tricyclic antidepressant (TCA) used in Europe and formerly in Japan for the treatment of depression.[1][2][3][4][5] It has imipramine-like effects; though, in a double-blind clinical trial against imipramine, dimetacrine was found to have lower efficacy in comparison and produced more weight loss and abnormal liver tests.[6][7]

Little is known about the pharmacology of dimetacrine,[8] but it can be inferred that it acts in a similar manner to other TCAs. If this is indeed the case, dimetacrine may induce severe cardiac toxicity in overdose (a side effect unique to the tricyclic class of antidepressants).

See also

Melitracen

References

  1. ↑ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8. https://books.google.com/books?id=_8TyJT0RfN0C&pg=PA2519. 
  2. ↑ "A Review of the Pharmacotherapy of Depression in Japan". Affective Disorders: Perspective on Basic Research and Clinical Practice. Tokyo: Seiwa Shoten. 1993. ISBN 978-0-87630-674-1. https://books.google.com/books?id=XLItppcgYugC&pg=PA117. 
  3. ↑ Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. 2007. ISBN 978-3-527-31058-6. 
  4. ↑ "[Dimethacrine (istonil), an acridane derivative with the antidepressive action]" (in de). Schweizerische Medizinische Wochenschrift 96 (48): 1616–1620. December 1966. PMID 6008540. 
  5. ↑ "[Contribution to the clinical evaluation of the antidepressive effect of dimethacrine (Istonil)]" (in de). Praxis 57 (20): 721–723. May 1968. PMID 5756370. 
  6. ↑ "A double-blind investigation of dimethacrine versus imipramine in hospitalized depressive states". International Journal of Clinical Pharmacology, Therapy and Toxicology 8 (3): 244–253. November 1973. PMID 4149236. 
  7. ↑ "Psychoactive Drugs: Antidepresants". Drug actions: basic principles and therapeutic aspects. Stuttgart, Germany: Medpharm Scientific Pub. 1995. ISBN 0-8493-7774-9. https://books.google.com/books?id=IvN4mZxraMkC&q=dimetacrine&pg=PA127. Retrieved January 30, 2013. 
  8. ↑ "Dimetacrine" (in en). PubChem. U.S. National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/compound/94280. 



Retrieved from "https://handwiki.org/wiki/index.php?title=Chemistry:Dimetacrine&oldid=3326045"