Chemistry:Quinupramine

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Short description: Tricyclic antidepressant
Quinupramine
Quinupramine.svg
Clinical data
Routes of
administration		Oral
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Elimination half-life33 hours
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
Chemical and physical data
FormulaC21H24N2
Molar mass304.437 g·mol−1

Quinupramine (brand names Kevopril, Kinupril, Adeprim, Quinuprine) is a tricyclic antidepressant (TCA) used in Europe for the treatment of depression.[1][2]

Pharmacologically, quinupramine acts in vitro as a strong muscarinic acetylcholine receptor antagonist (anticholinergic) and H1 receptor antagonist (antihistamine), moderate 5-HT2 receptor antagonist, and weak serotonin and norepinephrine reuptake inhibitor.[3] It has negligible affinity for the α1-adrenergic, α2-adrenergic, β-adrenergic, or D2 receptor.[3]

Clinically, quinupramine is reported to be stimulating similarly to imipramine, desipramine, and demexiptiline.[4] It can be inferred that its in vivo metabolites may have stronger effects on the reuptake of norepinephrine and/or serotonin than quinupramine itself.[citation needed]

References

  1. ↑ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 908. ISBN 3-88763-075-0. https://books.google.com/books?id=5GpcTQD_L2oC&q=quinupramine&pg=PA908. 
  2. ↑ Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. 2007. p. 248. ISBN 978-3-527-31058-6. https://books.google.com/books?id=yXD4QA-Y_Z0C&q=quinupramine&pg=PA248. 
  3. ↑ 3.0 3.1 "Receptor binding profile of quinupramine, a new tricyclic antidepressant". Japanese Journal of Pharmacology 36 (4): 455–460. December 1984. doi:10.1254/jjp.36.455. PMID 6098759. 
  4. ↑ Sleep: physiology, investigations, and medicine. New York: Kluwer Academic/Plenum. 2003. p. 233. ISBN 0-306-47406-9. https://books.google.com/books?id=IorPrIY6dOYC&q=quinupramine&pg=PA233. 



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