Chemistry:Melitracen

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Short description: Chemical compound
Melitracen
Skeletal formula of melitracen
Ball-and-stick model of the melitracen molecule
Clinical data
Trade namesAdaptol, Dixeran, Melixeran, Thymeol, Trausabun
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral, intramuscular injection
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC21H25N
Molar mass291.438 g·mol−1
3D model (JSmol)
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Melitracen (brand names Melixeran, Trausabun) is a tricyclic antidepressant (TCA), for the treatment of depression and anxiety.[1][2][3][4] In addition to single drug preparations, it is also available as Deanxit, marketed by Lundbeck, a combination product containing both melitracen and flupentixol.[5][6][7][8]

The pharmacology of melitracen has not been properly investigated and is largely unknown, but it is likely to act in a similar manner to other TCAs. Indeed, melitracen is reported to have imipramine and amitriptyline-like effects and efficacy against depression and anxiety, though with improved tolerability and a somewhat faster onset of action.[9][10]

See also

References

  1. ↑ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0. https://books.google.com/books?id=5GpcTQD_L2oC&q=melitracen&pg=PA643. 
  2. ↑ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8. https://books.google.com/books?id=x2Su3GKCvtsC&q=melitracen&pg=PA4129. 
  3. ↑ The Merck index: an encyclopedia of chemicals, drugs, and biologicals. Rahway, NJ: Merck Research Laboratories. 2001. ISBN 0-911910-13-1. https://archive.org/details/merckindexency00onei. 
  4. ↑ "Marketed Drugs and Drugs in DevelopmentVela". Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. 2007. ISBN 978-3-527-31058-6. https://books.google.com/books?id=yXD4QA-Y_Z0C&q=melitracen&pg=PA248. 
  5. ↑ European Drug Index (4th ed.). Boca Raton: CRC Press. 1998. ISBN 3-7692-2114-1. https://books.google.com/books?id=HiSdvzs2pPAC&q=melitracen&pg=PA327. 
  6. ↑ "Treatment of depressive anxiety states associated with psychosomatic symptoms. A double-blind multicentre clinical study: mianserin versus melitracen-flupentixol". Acta Psychiatrica Belgica 83 (5): 525–539. 1983. PMID 6670581. 
  7. ↑ "Flupenthixol and Melitracen in the management of trigeminal neuralgia". Dental Journal of Malaysia 8 (2): 37–38. April 1985. PMID 3917005. 
  8. ↑ "Clinical trial: a randomized controlled cross-over study of flupenthixol + melitracen in functional dyspepsia". Alimentary Pharmacology & Therapeutics 27 (11): 1148–1155. June 2008. doi:10.1111/j.1365-2036.2008.03677.x. PMID 18331614. 
  9. ↑ Meyler's Side Effects of Psychiatric Drugs (Meylers Side Effects). Amsterdam: Elsevier Science. 2008. ISBN 978-0-444-53266-4. https://books.google.com/books?id=s0XYvuPVgaAC&q=melitracen%20amitriptyline&pg=PA34. 
  10. ↑ "Antidepressives and Stimulants". Annual Reports in Medicinal Chemistry. 5. Boston: Academic Press. 1970. ISBN 0-12-040505-9. https://books.google.com/books?id=JIdV5T356CQC&q=melitracen&pg=PA13. 



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