Chemistry:SB-408124
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Short description: Chemical compound
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| Formula | C19H18F2N4O |
| Molar mass | 356.377 g·mol−1 |
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SB-408124 is a drug which is a non-peptide antagonist selective for the orexin receptor subtype OX1, with around 70x selectivity for OX1 over OX2 receptors, and improved oral bioavailability compared to the older OX1 antagonist SB-334867. It is used in scientific research into the function of orexinergic neurons in the body.[1][2]
References
- ↑ "Characterisation of the binding of [3H-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor"]. British Journal of Pharmacology 141 (2): 340–6. January 2004. doi:10.1038/sj.bjp.0705610. PMID 14691055.
- ↑ "Orexin-A modulates glutamatergic NMDA-dependent spinal reflex potentiation via inhibition of NR2B subunit". American Journal of Physiology. Endocrinology and Metabolism 295 (1): E117-29. July 2008. doi:10.1152/ajpendo.90243.2008. PMID 18477704.
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