Chemistry:Hydroxydione
From HandWiki
Short description: Chemical compound
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| Trade names | Viadril, Predion, Presuren |
| Other names | 21-Hydroxy-5β-pregnane-3,20-dione |
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| Formula | C21H32O3 |
| Molar mass | 332.484 g·mol−1 |
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Hydroxydione, as hydroxydione sodium succinate (INN, USAN, BAN) (brand names Viadril, Predion, and Presuren),[1][2][3] also known as 21-Hydroxy-5β-pregnane-3,20-dione, is a neuroactive steroid which was formerly used as a general anesthetic, but was discontinued due to incidence of thrombophlebitis in patients.[4] It was introduced in 1957,[3] and was the first neuroactive steroid general anesthetic to be introduced for clinical use, an event which was shortly preceded by the observation in 1954 of the sedative properties of progesterone in mice.[5]
Chemistry
Related compounds include alfadolone, alfaxolone, dihydrodeoxycorticosterone, ganaxolone, minaxolone, pregnanolone, and renanolone.
References
- ↑ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 531–. ISBN 978-3-88763-075-1. https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA531.
- ↑ Medicinal Chemistry. New Age International. 1 January 2005. pp. 63–. ISBN 978-81-224-1565-0. https://books.google.com/books?id=07g30rxCA0EC&pg=PA63.
- ↑ 3.0 3.1 William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. pp. 1863–. ISBN 978-0-8155-1856-3. https://books.google.com/books?id=_J2ti4EkYpkC&pg=PA1863.
- ↑ The Wondrous Story of Anesthesia. Springer Science & Business Media. 14 September 2013. pp. 632–. ISBN 978-1-4614-8441-7. https://books.google.com/books?id=H--3BAAAQBAJ&pg=PA632.
- ↑ Steroidal Activity in Experimental Animals and Man. Elsevier Science. 22 October 2013. pp. 447–. ISBN 978-1-4832-7299-3. https://books.google.com/books?id=BbLfBAAAQBAJ&pg=PA447.
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