Chemistry:Romifidine
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Short description: Chemical compound
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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | IV |
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| Formula | C9H9BrFN3 |
| Molar mass | 258.09 g·mol−1 |
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Romifidine is a drug that is used in veterinary medicine as a sedative mainly in large animals such as horses,[1] although it may be used in a wide variety of species.[2][3] It is not used in humans, but is closely related in structure to the commonly used drug clonidine.
Romifidine acts as an agonist at the α2 adrenergic receptor subtype. Side effects can include bradycardia and respiratory depression. It is often used alongside other sedative or analgesic drugs such as ketamine or butorphanol.[4][5] Yohimbine can be used as an antidote to rapidly reverse the effects.
References
- ↑ "Effect of romifidine on the nociceptive withdrawal reflex and temporal summation in conscious horses". American Journal of Veterinary Research 66 (11): 1992–8. November 2005. doi:10.2460/ajvr.2005.66.1992. PMID 16334961.
- ↑ "Pharmacokinetics of intramuscular ketamine in young ostriches premedicated with romifidine". Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine 54 (1): 48–50. February 2007. doi:10.1111/j.1439-0442.2007.00910.x. PMID 17359455.
- ↑ "Sedative and cardiorespiratory effects of three doses of romifidine in comparison with medetomidine in five cats". The Veterinary Record 162 (3): 82–7. January 2008. doi:10.1136/vr.162.3.82. PMID 18204032.
- ↑ "Comparison of morphine and butorphanol as pre-anaesthetic agents in combination with romifidine for field castration in ponies". Veterinary Anaesthesia and Analgesia 32 (1): 16–22. January 2005. doi:10.1111/j.1467-2995.2004.00184.x. PMID 15663735.
- ↑ "Cardiopulmonary effects of romifidine/ketamine or xylazine/ketamine when used for short duration anesthesia in the horse". Canadian Journal of Veterinary Research 68 (4): 274–82. October 2004. PMID 15581222.
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