Chemistry:MK-212
From HandWiki
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| Preferred IUPAC name
2-Chloro-6-(piperazin-1-yl)pyrazine | |
| Other names
CPP
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3D model (JSmol)
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| Properties | |
| C8H11ClN4 | |
| Molar mass | 198.65 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Tracking categories (test):
MK-212 (CPP or 6-chloro-2-(1-piperazinyl)pyrazine)[1] is a serotonin agonist.[2] It promotes the secretion of serum prolactin and cortisol in humans.[3]
Pharmacology
In an experiment performed by Clineschidt and colleagues, they dosed mice with varying concentrations of MK-212, and observed its effects.[4] The result correlated very well to binding of indolealkylamine receptors, such as the serotonin and tryptamine receptors, which shows four characteristics. Namely, increased frequency of muscle twitching, increased twitching of the head,[5] "an increase in the strength of the crossed extensor reflex in the acutely spinalized rat", and the cause of complex motor syndrome.[4]
See also
References
- ↑ "MK-212: a serotonin-like agonist in the CNS". General Pharmacology 10 (4): 287–90. 1979. doi:10.1016/0306-3623(79)90054-5. PMID 488663.
- ↑ "Prolactin and cortisol responses to MK-212, a serotonin agonist, in obsessive-compulsive disorder". Archives of General Psychiatry 47 (9): 833–9. September 1990. doi:10.1001/archpsyc.1990.01810210041006. PMID 2203327.
- ↑ "Stimulation of serum cortisol and prolactin secretion in humans by MK-212, a centrally active serotonin agonist". Biological Psychiatry 23 (8): 818–28. April 1988. doi:10.1016/0006-3223(88)90070-4. PMID 3365458.
- ↑ 4.0 4.1 "Central serotonin-like activity of 6-chloro-2-[1-piperazinyl]-pyrazine (CPP; MK-212)". European Journal of Pharmacology 44 (1): 65–74. July 1977. doi:10.1016/0014-2999(77)90117-0. PMID 885160.
- ↑ "Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells". British Journal of Pharmacology 128 (1): 13–20. September 1999. doi:10.1038/sj.bjp.0702751. PMID 10498829.
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