Chemistry:SNC-80
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Short description: Opioid analgesic drug
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| Other names | SNC-80 |
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| Formula | C28H39N3O2 |
| Molar mass | 449.639 g·mol−1 |
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SNC-80 is an opioid analgesic compound that selectively activates μ–δ opioid receptor heteromers[1] and is used in scientific research.[2] It was discovered in 1994.[3]
SNC-80 was the first non-peptide compound developed that was regarded as a highly selective agonist for the δ-opioid receptor.[4] It has been shown to produce useful analgesic,[5] antidepressant[6] and anxiolytic effects in animal studies,[7][8] but its usefulness is limited by producing convulsions at high doses,[9] and so SNC-80 is not used medically, although it is a useful compound in scientific research.
References
- ↑ "The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors". ACS Chemical Neuroscience 3 (7): 505–9. July 2012. doi:10.1021/cn3000394. PMID 22860219.
- ↑ "SNC 80 and related delta opioid agonists". Current Pharmaceutical Design 10 (7): 733–42. 2004. doi:10.2174/1381612043453054. PMID 15032699.
- ↑ "Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist". Journal of Medicinal Chemistry 37 (14): 2125–8. July 1994. doi:10.1021/jm00040a002. PMID 8035418.
- ↑ "SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist". The Journal of Pharmacology and Experimental Therapeutics 273 (1): 359–66. April 1995. PMID 7714789.
- ↑ "A comparison of the antinociceptive and adverse effects of the mu-opioid agonist morphine and the delta-opioid agonist SNC80". Basic & Clinical Pharmacology & Toxicology 97 (1): 39–51. July 2005. doi:10.1111/j.1742-7843.2005.pto_97107.x. PMID 15943758.
- ↑ "Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats". Psychopharmacology 182 (4): 588–96. November 2005. doi:10.1007/s00213-005-0138-9. PMID 16163520.
- ↑ "Delta opioid receptor ligands modulate anxiety-like behaviors in the rat". British Journal of Pharmacology 147 (8): 864–72. April 2006. doi:10.1038/sj.bjp.0706686. PMID 16491101.
- ↑ "Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents". Journal of Pharmacological Sciences 95 (3): 374–80. July 2004. doi:10.1254/jphs.FPJ04014X. PMID 15272214.
- ↑ "Electroencephalographic and convulsant effects of the delta opioid agonist SNC80 in rhesus monkeys". Pharmacology, Biochemistry, and Behavior 85 (2): 428–34. October 2006. doi:10.1016/j.pbb.2006.09.012. PMID 17112570.
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