Chemistry:WY-46824
From HandWiki
Short description: Chemical compound
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| Formula | C19H29ClN2O |
| Molar mass | 336.90 g·mol−1 |
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WY-46824 is a norepinephrine-dopamine reuptake inhibitor related to venlafaxine that was disclosed by Paige Mahaney, et al. of Wyeth in 2008.[1] The compound actually appears in an article a year earlier in 2007 but is not the main focus of the work.[2] It has NET binding of 46 nM, DAT = 58 nM and SERT = 18795 nM. The racemic compound was resolved into its constituent enantiomers, and the (S) enantiomer is the more active one. The N-desmethyl derivative shows similar activity.
References
- ↑ "Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors". Journal of Medicinal Chemistry 51 (13): 4038–49. July 2008. doi:10.1021/jm8002262. PMID 18557608.
- ↑ "Desvenlafaxine succinate identifies novel antagonist binding determinants in the human norepinephrine transporter". The Journal of Pharmacology and Experimental Therapeutics 323 (2): 720–9. November 2007. doi:10.1124/jpet.107.125716. PMID 17673606.
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