Chemistry:Lidoflazine
From HandWiki
Short description: Chemical compound
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| Formula | C30H35F2N3O |
| Molar mass | 491.627 g·mol−1 |
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| Melting point | 159 to 161 °C (318 to 322 °F) |
| Solubility in water | Almost insoluble in water(<0.01%); Very soluble in chloroform(>50%); mg/mL (20 °C) |
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Lidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action.[1] Lidoflazine was discovered at Janssen Pharmaceutica in 1964.
Physical properties
Solubility at room temperature
Extracted from[1]
| Solvent | 0.01
N |
0.1
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| % | pH | % | pH | |
| Hydrochloric Acid | 0.4 | 3.0 | 0.7 | 1.9 |
| Tartaric Acid | 0.3 | 3.1 | 1.0 | 2.5 |
| Citric Acid | 0.3 | 3.1 | 0.5 | 2.5 |
| Lactic Acid | 0.2 | 3.4 | 0.7 | 2.9 |
| Acetic Acid | 0.1 | 3.5 | 0.4 | 3.8 |
References
- ↑ 1.0 1.1 "The cardiovascular pharmacology of lidoflazine, a long-acting coronary vasodilator". The Journal of Pharmacology and Experimental Therapeutics 152 (2): 265–274. May 1966. PMID 5944369. http://jpet.aspetjournals.org/cgi/content/abstract/152/2/265.
Further reading
- "Stimulation of the coronary collateral circulation by lidoflazine (R 7904)". Naunyn-Schmiedebergs Archiv Fur Experimentelle Pathologie und Pharmakologie 252 (1): 1–8. November 1965. doi:10.1007/bf00246424. PMID 4222721.
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