Chemistry:Lidoflazine
From HandWiki
Lidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action.[1] Lidoflazine was discovered at Janssen Pharmaceutica in 1964. In 2025 Lidoflazine has also been reported to interact with tubulin and inhibit its polymerization.[2]
Physical properties
Solubility at room temperature
Extracted from[1]
| Solvent | 0.01
N |
0.1
N | ||
| % | pH | % | pH | |
| Hydrochloric Acid | 0.4 | 3.0 | 0.7 | 1.9 |
| Tartaric Acid | 0.3 | 3.1 | 1.0 | 2.5 |
| Citric Acid | 0.3 | 3.1 | 0.5 | 2.5 |
| Lactic Acid | 0.2 | 3.4 | 0.7 | 2.9 |
| Acetic Acid | 0.1 | 3.5 | 0.4 | 3.8 |
References
- ↑ 1.0 1.1 "The cardiovascular pharmacology of lidoflazine, a long-acting coronary vasodilator". The Journal of Pharmacology and Experimental Therapeutics 152 (2): 265–274. May 1966. doi:10.1016/S0022-3565(25)27319-0. PMID 5944369. http://jpet.aspetjournals.org/cgi/content/abstract/152/2/265.
- ↑ "NanoDSF Screening for Anti-tubulin Agents Uncovers New Structure–Activity Insights". Journal of Medicinal Chemistry. 2025. doi:10.1021/acs.jmedchem.5c01008.
Further reading
- "Stimulation of the coronary collateral circulation by lidoflazine (R 7904)". Naunyn-Schmiedebergs Archiv für Experimentelle Pathologie und Pharmakologie 252 (1): 1–8. November 1965. doi:10.1007/bf00246424. PMID 4222721.
 |  |
- ↑ "Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules". Acta Pharmacologica Sinica 32 (6): 781–788. June 2011. doi:10.1038/aps.2011.70. PMID 21623390.
