Chemistry:Befuraline
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Short description: Psychoactive drug of the piperazine chemical class
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| Formula | C20H20N2O2 |
| Molar mass | 320.392 g·mol−1 |
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Befuraline (DIV-154) is a psychoactive drug and member of the piperazine chemical class which was developed in Germany in the 1970s.[1] Befuraline has stimulant and antidepressant effects and has seen some use in Germany and France , although it has never become widely used.[2] Befuraline's active metabolite benzylpiperazine is likely to contribute to its effects.
Synthesis
A one-step coupling between coumarilic acid (benzofuran-2-carboxylic acid) [496-41-3] (1) and benzylpiperazine (BzP) (2) gives an amide, and hence Befuraline (3).
See also
References
- ↑ 1.0 1.1 "Synthesis and pharmacological activity of befuraline (N-benzo[b]furan-2-ylcarbonyl-N'-benzylpiperazine), a new antidepressant compound". Arzneimittel-Forschung 29 (2): 193–204. 1979. PMID 582130.
- ↑ "Befuraline, its safety and efficacy in depressed inpatients". Pharmacopsychiatry 18 (6): 351–5. November 1985. doi:10.1055/s-2007-1017396. PMID 4089015.
- ↑ DE2157424 idem Rolf-Ortwin Weber, Alfons Soder, Istvan Boksay, U.S. Patent 4,374,990 (1980 to Hoechst Aktiengesellschaft).
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