Chemistry:EGIS-12,233

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Short description: Chemical compound
EGIS-12,233
EGIS-12,233.svg
Clinical data
ATC code
  • none
Identifiers
PubChem CID
Chemical and physical data
FormulaC24H28Cl3N3O
Molar mass480.86 g·mol−1
3D model (JSmol)
  (verify)

EGIS-12,233 is a drug with applications in scientific research, acting as a potent and selective antagonist for both the 5-HT6 and 5-HT7 serotonin receptor subtypes, with good selectivity over other receptors.[1] It has been shown to increase dopamine release in cochlear tissue, suggesting a role for the 5-HT6 and 5-HT7 receptors in regulation of the hearing system.[2]

References

  1. ↑ "(Phenylpiperazinyl-butyl)oxindoles as selective 5-HT7 receptor antagonists". Journal of Medicinal Chemistry 51 (8): 2522–32. April 2008. doi:10.1021/jm070279v. PMID 18361484. 
  2. ↑ "5-HT6/7 receptor antagonists facilitate dopamine release in the cochlea via a GABAergic disinhibitory mechanism". Neurochemical Research 33 (11): 2364–72. November 2008. doi:10.1007/s11064-008-9796-4. PMID 18663573. 



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