Chemistry:AD-1211
From HandWiki
Short description: Opioid analgesic drug
 | |
| Clinical data | |
|---|---|
| Other names | AD-1211 |
| ATC code |
|
| Identifiers | |
| |
| CAS Number |
|
| PubChem CID | |
| ChemSpider | |
| UNII | |
| Chemical and physical data | |
| Formula | C23H30N2O |
| Molar mass | 350.506 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
| (verify) | |
AD-1211 is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. It is chemically a 1-substituted-4-prenyl-piperazine derivative, which is structurally unrelated to most other opioid drugs. The (S)-enantiomers in this series are more active as opioid agonists, but the less active (R)-enantiomer of this compound, AD-1211, is a mixed agonist–antagonist at opioid receptors with a similar pharmacological profile to pentazocine,[1] and has atypical opioid effects with little development of tolerance or dependence seen after extended administration in animal studies.[2][3]
See also
- Diphenidine
- Diphenpipenol
- Ephenidine
- Fluorolintane
- Lanicemine
- Lefetamine
- Methoxphenidine (MXP)
- MT-45
- Remacemide
- AH-7921
References
- ↑ "Synthesis and structure-activity relationships of 1-substituted 4-(1,2-diphenylethyl)piperazine derivatives having narcotic agonist and antagonist activity". Journal of Medicinal Chemistry 30 (10): 1779–87. October 1987. doi:10.1021/jm00393a017. PMID 3656354.
- ↑ "Analgesic and other pharmacological activities of a new narcotic antagonist analgesic (−)-1-(3-methyl-2-butenyl)-4-[2-(3-hydroxyphenyl)-1-phenylethyl]-piperazine and its enantiomorph in experimental animals". The Journal of Pharmacy and Pharmacology 32 (9): 635–42. September 1980. doi:10.1111/j.2042-7158.1980.tb13020.x. PMID 6107365.
- ↑ "Central actions of AD-1211, an analgesic lacking common opiate features". European Journal of Pharmacology 106 (2): 345–56. November 1984. doi:10.1016/0014-2999(84)90722-2. PMID 6529980.
 |  |
