Chemistry:B777-81
From HandWiki
Short description: Experimental antidepressant
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| Other names | BRN 6066682 |
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| Formula | C18H22N2O |
| Molar mass | 282.387 g·mol−1 |
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B-777-81 is an antidepressant drug candidate.[1]
B777-81 works by reversing reserpine and tetrabenazine-induced ptosis in a similar manner to that of imipramine, but with a shorter duration of action. It also antagonizes reserpine-induced hypothermia but it is without effect on the decrease in locomotor activity or catalepsy following reserpine. In vitro, B777-81 inhibited 5-HT uptake in platelets, potentiated the effect of NA[clarification needed] on isolated vas deferens and had less anticholinergic effect than imipramine in the isolated ileum.[2][3]
References
- ↑ "B-777-81". Drugs of the Future 8 (5): 387. 1983. doi:10.1358/dof.1983.008.05.65796.
- ↑ "4 Recent Progress in the Development of New Antidepressant Drugs". Progress in Medicinal Chemistry. 23. Elsevier. 1986. pp. 121–185. doi:10.1016/S0079-6468(08)70342-4. ISBN 978-0-444-80802-8.
- ↑ "Classification of New CNS-active Compounds by a Two-lever Drug Discrimination Procedure.". Pharmacopsychiatry 18 (1): 141–142. January 1985. doi:10.1055/s-2007-1017346.
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