Chemistry:MSX-4
From HandWiki
MSX-4 is a selective adenosine A2A receptor antagonist used in scientific research.[1] It is a water-soluble amino acid ester prodrug of MSX-2, the active metabolite of the drug.[2][1] MSX-4 reverses the motivational deficits induced by the dopamine D2 receptor antagonist eticlopride in animals and hence has the capacity to produce pro-motivational effects.[3][4] MSX-4 was first described in the scientific literature by 2008.[1]
See also
- Istradefylline
- MSX-3
References
- ↑ 1.0 1.1 1.2 "Synthesis and properties of a new water-soluble prodrug of the adenosine A 2A receptor antagonist MSX-2". Molecules 13 (2): 348–359. February 2008. doi:10.3390/molecules13020348. PMID 18305423.
- ↑ "Prodrug approaches for enhancing the bioavailability of drugs with low solubility". Chemistry & Biodiversity 6 (11): 2071–2083. November 2009. doi:10.1002/cbdv.200900114. PMID 19937841.
- ↑ "The Psychopharmacology of Effort-Related Decision Making: Dopamine, Adenosine, and Insights into the Neurochemistry of Motivation". Pharmacol Rev 70 (4): 747–762. October 2018. doi:10.1124/pr.117.015107. PMID 30209181.
- ↑ "The novel adenosine A(2A) antagonist prodrug MSX-4 is effective in animal models related to motivational and motor functions". Pharmacol Biochem Behav 102 (4): 477–487. October 2012. doi:10.1016/j.pbb.2012.06.009. PMID 22705392.
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