From HandWiki
Clinical data
Trade namesEucapil
Other namesFluridil; BP-766
Routes of
Drug classNonsteroidal antiandrogen
ATC code
  • None
CAS Number
PubChem CID
Chemical and physical data
Molar mass403.237 g·mol−1
3D model (JSmol)

Topilutamide, known more commonly as fluridil and sold under the brand name Eucapil, is an antiandrogen medication which is used in the treatment of pattern hair loss in men and women.[6][1][2][3][4][5] It is used as a topical medication and is applied to the scalp.[1][2][3][4][5]

Topilutamide is a nonsteroidal antiandrogen (NSAA), or an antagonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT).[1][2][3][4][5]

Topilutamide was introduced for medical use in 2003.[7] It is marketed only in the Czech Republic and Slovakia.[8]

Medical uses

Topilutamide is used as a topical medication in the treatment of pattern hair loss in men and women.[1][2][3][4][5]

Available forms

As Eucapil, topilutamide is available as a 2% topical formulation intended for application to the scalp.[4]



Topilutamide is an antagonist of the AR, the biological target of androgens like testosterone and DHT.[1][2][3][4][5]


Topilutamide is a topical medication and is applied to the scalp.[1][2][3][4][5]


Topilutamide is a nonsteroidal compound and is closely related to other NSAAs such as flutamide and bicalutamide.[7]


Topilutamide was introduced for medical use in 2003.[7]

Society and culture

Generic names

Topilutamide is the generic name of the drug and its INN.[9][10][11] It is also known more commonly as fluridil.[6] Topilutamide is also known by its former developmental code name BP-766.[6]

Brand names

Topilutamide is marketed by Interpharma Praha under the brand name Eucapil.[7][3]


Topilutamide is available only in Europe in the Czech Republic and Slovakia.[8]

See also


  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 "Fluridil, a rationally designed topical agent for androgenetic alopecia: first clinical experience". Dermatol Surg 28 (8): 678–85. 2002. doi:10.1046/j.1524-4725.2002.02017.x. PMID 12174057. 
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Robert S. Haber; Dowling Bluford Stough (2006). Hair Transplantation. Elsevier Health Sciences. pp. 7–. ISBN 1-4160-3104-9. 
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Scripta Medica. 2006. pp. 45, 53–54. "Fluridil was developed as a topical antiandrogen, suitable for the treatment of hyperandrogenic skin syndromes. The cosmetic product Eucapil® containing 2% fluridil in isopropanol was tested in women with AGA in a 9-month open study. [...] In a clinical study conducted at our facility, fluridil in solution (Eucapil®, Interpharma Praha, Czech Republic) has been shown to be effective and safe in the treatment of men with androgenetic alopecia (30, 31)." 
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Marc R. Avram; Nicole E. Rogers (30 November 2009). Hair Transplantation. Cambridge University Press. pp. 11–. ISBN 978-1-139-48339-1. 
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Men's Health, Third Edition. CRC Press. 29 January 2009. pp. 362–. ISBN 978-1-4398-0807-8. 
  6. 6.0 6.1 6.2 Seligson, Allen L; Campion, Brian K; Brown, Jason W; Terry, Ron C; Kucerova, Renata; Bienova, Martina; Hajduch, Marian; Sovak, Milos (2003). "Development of fluridil, a topical suppressor of the androgen receptor in androgenetic alopecia". Drug Development Research 59 (3): 292–306. doi:10.1002/ddr.10166. ISSN 0272-4391. 
  7. 7.0 7.1 7.2 7.3 "Non-steroidal steroid receptor modulators". IDrugs 9 (7): 488–94. 2006. doi:10.2174/0929867053764671. PMID 16821162. 
  8. 8.0 8.1 "Androgenetic Alopecia,Hair loss,Eucapil". 
  9. Chambers, Michael. "ChemIDplus - 260980-89-0 - YCNCRLKXSLARFT-UHFFFAOYSA-N - Topilutamide [INN - Similar structures search, synonyms, formulas, resource links, and other chemical information."]. 
  10. "Microsoft Word - final_PL91.doc". 
  11. United States International Trade Commission (2008). Modifications to the Harmonized Tariff Schedule of the United States to Implement the Dominican Republic-Central America-United States Free Trade Agreement With Respect to Costa Rica. DIANE Publishing. pp. 18–. ISBN 978-1-4578-1723-6. 


| name = Androgens and antiandrogens
| title = Androgens and antiandrogens
| state = collapsed
| listclass = hlist
| groupstyle = text-align:center;
| group1 = Androgens
(incl. AAS)

| list1 =

  | group3 = Antigonadotropins
  | list3 =
  | group4 = Others
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| liststyle = background:#DDDDFF;
| list3 =
See also
Androgen receptor modulators
Estrogens and antiestrogens
Progestogens and antiprogestogens
List of androgens/anabolic steroids